Hippocampal CA2 pyramidal cells project into both the neighboring CA1 and CA3 subfields, leaving them well positioned to influence network physiology and information processing for memory and space. While recent work ...
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Hippocampal CA2 pyramidal cells project into both the neighboring CA1 and CA3 subfields, leaving them well positioned to influence network physiology and information processing for memory and space. While recent work has suggested unique roles for CA2, including encoding position during immobility and generating ripple oscillations, an interventional examination of the integrative functions of these connections has yet to be reported. Here we demonstrate that CA2 recruits feedforward inhibition in CA3 and that chronic genetically engineered shutdown of CA2-pyramidal-cell synaptic transmission consequently results in increased excitability of the recurrent CA3 network. In behaving mice, this led to spatially triggered episodes of network-wide hyperexcitability during exploration accompanied by the emergence of high-frequency discharges during rest. These findings reveal CA2 as a regulator of network processing in hippocampus and suggest that CA2-mediated inhibition in CA3 plays a key role in establishing the dynamic excitatory and inhibitory balance required for proper network function.
Several workers have concluded that Gabor alignment tasks are performed by using central tendencies of the micropatterns as a cue, One reason for this conclusion was that the 3-Gabor alignment task is performed equall...
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Several workers have concluded that Gabor alignment tasks are performed by using central tendencies of the micropatterns as a cue, One reason for this conclusion was that the 3-Gabor alignment task is performed equally well whether the orientations of the patches are collinear or orthogonal to the group orientation, We wished to find out if the orientation of the micropatterns has any effect on performance, We tested subjects in 3-micropattern alignment tasks using a variety of orientational conditions, If three vertically-aligned Gabor patches were vertical, horizontal or both, or if bullseye or Gaussian blobs were used, no difference in performance was found, If, however, the orientation of the patches was randomized, performance became much worse, Similarly, if the three patches were at 45 deg, thresholds were raised, The effect of orientation was maintained across different spatial frequencies, Control conditions involving randomization of the phase of the sinusoidal carrier, or jitter on the size of Gaussian blobs, confirmed that a central tendency of the micropatterns was indeed being used by subjects, indicating that the role of orientation in this task is that of a mask, rather than of a cue. (C) 1998 Elsevier Science Ltd. All rights reserved.
This study describes the visual information coding ability of single neurons in the suprageniculate nucleus (Sg), and provides new data concerning the visual information flow in the suprageniculate/anterior ectosylvia...
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This study describes the visual information coding ability of single neurons in the suprageniculate nucleus (Sg), and provides new data concerning the visual information flow in the suprageniculate/anterior ectosylvian pathways of the feline brain. The visual receptive fields of the Sg neurons have an internal structure rather similar to that described earlier in the anterior ectosylvian visual area (AEV). The majority of the Sg units can provide information via their discharge rate at the site of the visual stimulus within their large receptive fields. This suggests that they may serve as panoramic localizers. The sites of maximum responsivity of the Sg neurons are distributed over the whole investigated part of the visual field. There is no significant difference between the distributions of spatial location of maximum sensitivity of the AEV and the Sg neurons. The mean visual response latency of the Sg units was found to be significantly shorter than the mean latency of the AEV neurons, but there was no difference between the shortest latency values of the thalamic and the cortical single-units. This suggests that the visual information flows predominantly from the Sg to the AEV, though the cortico-thalamic route is also active. The Sg seems to represent a thalamic nucleus rather similar in function to both the first-order relays and the higher-order thalamic nuclei. These results, together with the fact that the superior colliculus provides the common ascending source of information to the suprageniculate/anterior ectosylvian pathway, suggest a unique function of the AEV and the Sg in sensorimotor integration. (c) 2005 Elsevier Inc. All rights reserved.
Allocentric and egocentric reference frames are used to code the spatial position of action targets in reference to objects in the environment, i.e., relative to landmarks (allocentric), or the observer (egocentric). ...
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Allocentric and egocentric reference frames are used to code the spatial position of action targets in reference to objects in the environment, i.e., relative to landmarks (allocentric), or the observer (egocentric). Previous research investigated reference frames in isolation, for example, by shifting landmarks relative to the target and asking participants to reach to the remembered target location. Systematic reaching errors were found in the direction of the landmark shift and used as a proxy for allocentric spatial coding. Here, we examined the interaction of both allocentric and egocentric reference frames by shifting the landmarks as well as the observer. We asked participants to encode a three-dimensional configuration of balls and to reproduce this configuration from memory after a short delay followed by a landmark or an observer shift. We also manipulated the number of landmarks to test its effect on the use of allocentric and egocentric reference frames. We found that participants were less accurate when reproducing the configuration of balls after an observer shift, which was reflected in larger configurational errors. In addition, an increase in the number of landmarks led to a stronger reliance on allocentric cues and a weaker contribution of egocentric cues. In sum, our results highlight the important role of egocentric cues for allocentric spatial coding in the context of memory-guided actions.
Motion contained within a static object can cause illusory position shifts toward the direction of internal motion. Here we present data suggesting this illusion is driven by modulations of apparent contrast. We obser...
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Motion contained within a static object can cause illusory position shifts toward the direction of internal motion. Here we present data suggesting this illusion is driven by modulations of apparent contrast. We observe position shifts at blurred stimulus regions without corresponding changes to internal structure, and find that low-contrast targets are more difficult to detect at the trailing, as opposed to leading, edges of movement. Motion induced position shifts are also shown to occur without conscious appreciation of motion direction. Our data suggests that motion can influence spatial coding via interactions that modulate apparent contrast, thereby changing the regions of the stimulus that are visible. (C) 2007 Elsevier Ltd. All rights reserved.
A convergent series of studies in monkeys and man suggests that the computation of visual space is performed in several brain regions for different behavioural purposes, Among these multiple spatial areas, the ventral...
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A convergent series of studies in monkeys and man suggests that the computation of visual space is performed in several brain regions for different behavioural purposes, Among these multiple spatial areas, the ventral intraparietal cortex, the putamen and the ventral aspect of the premotor cortex (area 6) contain a system for representing visual space near the face (peripersonal space). In these cerebral areas some neurons are bimodal: they have tactile receptive fields on the face, and they can also be driven by visual stimuli located near the tactile field. The spatial correspondence between the visual and tactile receptive fields provides a map of near visual space coded in body-part-centred co-ordinates, In the present study we demonstrate for the first time the existence of a visual peripersonal space centred on the face in humans, In patients with right hemispheric lesions, visual stimuli delivered in the space near the ipsilesional side of the face extinguished tactile stimuli on the contralesional side (cross-modal visuotactile extinction) to the same extent as did an ipsilesional tactile stimulation (unimodal tactile extinction). Furthermore, a visual stimulus presented in the proximity of the contralesional side of the face improved the detection of a left tactile stimulus: i.e. under bilateral tactile presentation patients were more accurate to report the presence of a left tactile stimulus when a simultaneous visual stimulus was presented near the left side of the face. However, when visual stimuli were delivered far from the face, visuotactile extinction and visuotactile facilitation effects were dramatically reduced. These findings are consistent with the hypothesis of a representation of visual peripersonal space coded in body-part-centred co-ordinates, and they provide a striking demonstration of the modularity of human visual space.
Retinal motion can modulate visual sensitivity. For instance, low contrast drifting waveforms (targets) can be easier to detect when abutting the leading edges of movement in adjacent high contrast waveforms (inducers...
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Retinal motion can modulate visual sensitivity. For instance, low contrast drifting waveforms (targets) can be easier to detect when abutting the leading edges of movement in adjacent high contrast waveforms (inducers), rather than the trailing edges. This target-inducer interaction is contingent on the adjacent waveforms being consistent with one another - in-phase as opposed to out-of-phase. It has been suggested that this happens because there is a perceptually explicit predictive signal at leading edges of motion that summates with low contrast physical input - a 'predictive summation'. Another possible explanation is a phase sensitive 'spatial summation', a summation of physical inputs spread across the retina (not predictive signals). This should be non-selective in terms of position - it should be evident at leading, adjacent, and at trailing edges of motion. To tease these possibilities apart, we examined target sensitivity at leading, adjacent, and trailing edges of motion. We also examined target sensitivity adjacent to flicker, and for a stimulus that is less susceptible to spatial summation, as it sums to grey across a small retinal expanse. We found evidence for spatial summation in all but the last condition. Finally, we examined sensitivity to an absence of signal at leading and trailing edges of motion, finding greater sensitivity at leading edges. These results are inconsistent with the existence of a perceptually explicit predictive signal in advance of drifting waveforms. Instead, we suggest that phase-contingent target-inducer modulations of sensitivity are explicable in terms of a directionally modulated spatial summation. (C) 2014 Published by Elsevier Ltd.
Previous psychological experiments have indicated the existence of a visual-proprioceptive interaction in spatial stimulus-response compatibility (SSRC) tasks, but there is little specific information on the neural ba...
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Previous psychological experiments have indicated the existence of a visual-proprioceptive interaction in spatial stimulus-response compatibility (SSRC) tasks, but there is little specific information on the neural basis of such interaction in humans. Using functional magnetic resonance imaging (fMRI), we compared the neural activity associated with two different aspects of spatial coding: the coding of the "internal" spatial position of motor-response effectors (i.e., the position of body parts) as obtained through proprioception, and the coding of "external" positions, i.e., the positions of visual stimuli. A 2x2 factorial design was used to investigate the spatial compatibility (incompatible versus compatible) between a visual stimulus and hand position (crossed versus uncrossed). The subjects were instructed to respond to stimuli presented to the right or left visual field with either the ipsilateral (compatible condition) or the contralateral hand (incompatible condition). The incompatible condition produced stronger activation in the bilateral superior parietal lobule, inferior parietal lobule, and bilateral superior frontal gyrus than the compatible condition. The crossed-hand condition produced stronger activation in the bilateral precentral gyrus, superior frontal gyrus, superior parietal lobule, and superior temporal gyrus than the uncrossed-hand condition. These results suggest that activity in the frontal-parietal regions is related to two functions: (1) representation of the visual stimulus-motor response spatial configuration in an SSRC task, and (2) integration between external visual and internal proprioceptive sensory information. The activation in the superior temporal gyrus was not affected by the visual stimulus-motor response spatial configuration in an SSRC task;rather, it was affected by the crossed-hand posture. Thus, it seems to be related to representing internal proprioceptive sensory information necessary to carry out motor actions.
Previous reports have argued that single neurons in the ventral premotor cortex of rhesus monkeys (PMv, the ventrolateral part of Brodmann's area 6) typically show spatial response fields that are independent of g...
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Previous reports have argued that single neurons in the ventral premotor cortex of rhesus monkeys (PMv, the ventrolateral part of Brodmann's area 6) typically show spatial response fields that are independent of gaze angle. We reinvestigated this issue for PMv and also explored the adjacent prearcuate cortex (PAv, areas 12 and 45). Two rhesus monkeys were operantly conditioned to press a switch and maintain fixation on a small visual stimulus (0.2-degrees x 0.2-degrees) while a second visual stimulus (1-degrees x 1-degrees or 2-degrees x 2-degrees) appeared at one of several possible locations on a video screen. When the second stimulus dimmed, after an unpredictable period of 0.4-1.2 s, the monkey had to quickly release the switch to receive liquid reinforcement. By presenting stimuli at fixed screen locations and varying the location of the fixation point, we could determine whether single neurons encode stimulus location in ''absolute space'' or any other coordinate system independent of gaze. For the vast majority of neurons in both PMv (90%) and PAv (94%), the apparent response to a stimulus at a given screen location varied significantly and dramatically with gaze angle. Thus, we found little evidence for gaze-independent activity in either PMv or PAv neurons. The present result in frontal cortex resembles that in posterior parietal cortex, where both retinal image location and eye position affect responsiveness to visual stimuli.
Odours are represented as unique combinations of activated glomeruli in the antennal lobes of insects. Receptor neurons arborizing in the glomeruli are not only qualitatively selective, but in addition respond to vari...
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Odours are represented as unique combinations of activated glomeruli in the antennal lobes of insects. Receptor neurons arborizing in the glomeruli are not only qualitatively selective, but in addition respond to variations in stimulus concentration. As each glomerulus likely represents a single receptor neuron type, optical recordings of calcium changes in insect antennal lobes show how concentration variations affect a large population of afferents. We measured the glomerular responses in the moth Spodoptera littoralis to different concentrations of plant-related odorants. Localized calcium responses were shown to correspond to individual glomeruli. We found that the dynamic range of glomerular responses spanned 3-4 log units of concentration and the most strongly responding glomeruli often reached a plateau at high stimulus doses. Further, we showed that the single most active glomerulus was often not the same across concentrations. However, if the principal glomerulus moved, it was generally to an adjacent or proximal glomerulus. As concentration increased, a higher number of glomeruli became activated. Correlations of glomerular representations of the same compound at different doses decreased as the difference in concentration increased. Moreover, representations evoked by different odorants were more correlated at high than at low doses, which means that the uniqueness of activity patterns decreased with increasing concentration. Thus, if odours are coded as spatial patterns of glomerular activity, as has been suggested, these olfactory codes are not persistent across concentrations.
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