The ability of biomacromolecules to coordinate fast reaction events in their active centers with slow rearrangements of their structure is focused upon. Under real conditions of many sequential reaction turnovers of t...
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The ability of biomacromolecules to coordinate fast reaction events in their active centers with slow rearrangements of their structure is focused upon. Under real conditions of many sequential reaction turnovers of the macromolecule, the structural shifts caused by single turnovers can be of cumulative character. This, in turn, leads to drastic threshold-like changes of the reaction cycle. In this way, the creative role of dynamical substrate-conformation interactions in the formation of functional regimes of the macromolecule is consistently uncovered. (C) 2009 Wiley Periodicals, Inc. Int J Quantum Chem 110: 62-66, 2010
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