We are concerned with the existence of blowing-up solutions to the following boundary value problem -Delta u=lambda V(x)e(u)-4 pi N delta(0 )in B-1, u = 0 on partial derivative B-1, where B-1 is the unit ball in R-2 c...
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We are concerned with the existence of blowing-up solutions to the following boundary value problem -Delta u=lambda V(x)e(u)-4 pi N delta(0 )in B-1, u = 0 on partial derivative B-1, where B-1 is the unit ball in R-2 centered at the origin, V(x)is a positive smooth potential, Nis a positive integer (N >= 1). Here delta(0) defines the Dirac measure with pole at 0, and lambda >0 is a small parameter. We assume that N=1 and, under some suitable assumptions on the derivatives of the potential Vat 0, we find a solution which exhibits a non-simple blow-up profile as lambda -> 0(+).
A previous study of lactate dehydrogenase (LDH Jin gingival crevicular fluid (GCF) suggested that the concentration is 10 to 25 times that of serum (X=2300 international units/I versus 100 IU/1 for serum). That study ...
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A previous study of lactate dehydrogenase (LDH Jin gingival crevicular fluid (GCF) suggested that the concentration is 10 to 25 times that of serum (X=2300 international units/I versus 100 IU/1 for serum). That study used capillary tubes to collect microliter amounts of GCF. Since invasive collection techniques can influence GCF flow, we evaluated LDH activity in GCF collected by filter strips. GCF was collected in a standardized fashion from 10 subjects with mild inflammation (GI=0.5–1.0) and 10 subjects without evidence of gingival inflammation (GI=0). Our results indicate that LDH volume activity was greater for subjects with GI=0 x= 105.529 IV/l) than for subjects with GI=0.5–1.0 (X;=77,66 1 IU/1). but the difference was not significant. LDH total unit activity was significantly greater in subjects with GI=0.5–1.0 versus GI=0 (X=0.048 IU versus X=0.0242 IU. P<0.0001). The relationship of LDH volume activity to GCF volume, the regression lines fit to the data, and calculation of LDH total unit activity were important for analysis of enzyme activity in GCF.
Neuroendocrine neoplasms (NENs) are relatively rare neoplasms with 6.4-times increasing age-adjusted annual incidence during the last four decades. NENs arise from neuroendocrine cells, which release hormones in respo...
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Neuroendocrine neoplasms (NENs) are relatively rare neoplasms with 6.4-times increasing age-adjusted annual incidence during the last four decades. NENs arise from neuroendocrine cells, which release hormones in response to neuronal stimuli and they are distributed into organs and tissues. The presentation and biological behaviour of the NENs are highly heterogeneous, depending on the organ. The increased incidence is mainly due to increased awareness and improved detection methods both in the majority of sporadic NENs (non-inherited), but also the inherited groups of neoplasms appearing in at least ten genetic syndromes. The most important one is multiple endocrine neoplasia type 1 (MEN-1), caused by mutations in the tumour suppressor gene MEN1. MEN-1 has been associated with different tumour manifestations of NENs e.g. pancreas, gastrointestinal tract, lungs, thymus and pituitary. Pancreatic NENs tend to be less aggressive when arising in the setting of MEN-1 compared to sporadic pancreatic NENs. There have been very important improvements over the past years in both genotyping, genetic counselling and family screening, introduction and validation of various relevant biomarkers, as well as newer imaging modalities. Alongside this development, both medical, surgical and radionuclide treatments have also advanced and improved morbidity, quality of life and mortality in many of these patients. Despite this progress, there is still space for improving insight into the genetic and epigenetic factors in relation to the biological mechanisms determining NENs as part of MEN-1. This review gives a comprehensive update of current evidence for co-occurrence, diagnosis and treatment of MEN-1 and neuroendocrine neoplasms and highlight the important progress now finding its way to international guidelines in order to improve the global management of these patients.
Design and modeling of geometric diodes can be really challenging as it requires a rigorous quantum analysis at the nanoscale, accurate enough to capture the asymmetric behavior of charge transport. In this paper, we ...
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Design and modeling of geometric diodes can be really challenging as it requires a rigorous quantum analysis at the nanoscale, accurate enough to capture the asymmetric behavior of charge transport. In this paper, we present a full-wave Time-Dependent Schrodinger Equation (TDSE) approach to model coherent transport in a two-dimensional geometric diode defined by an asymmetric taper of the domain where the charges are confined. The proposed solution clearly shows asymmetric transport, and provides a description of the rectification behavior in response to a parametric change. In general, the above model can account for even more complex geometries in order to optimize diodes performance.
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