New dequalinium analogues and related heteroaromatic systems were synthesized and evaluated for inhibition of protein kinase Cot. In vitro assays with recombinant human PKC alpha showed that the number of the aromatic...
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New dequalinium analogues and related heteroaromatic systems were synthesized and evaluated for inhibition of protein kinase Cot. In vitro assays with recombinant human PKC alpha showed that the number of the aromatic ring head groups as well as their electron-richness, are critical factors that determine potency. The inhibitory strengths of the synthesized compounds are shown to correlate well with Mulliken charges on the head group ring nitrogen atoms making it possible to design likely candidate molecules having improved protein kinase C alpha inhibitory activity. (c) 2006 Elsevier Ltd. All rights reserved.
If a continuous function f is approximated by elements of a Haar space in the maximum norm on an interval, the error curve of the best approximation has well known alternation properties. It is shown that if f is adjo...
If a continuous function f is approximated by elements of a Haar space in the maximum norm on an interval, the error curve of the best approximation has well known alternation properties. It is shown that if f is adjoined to the Haar space all zeros of the error function are monotonously increasing functions of the endpoints, and that under an additional hypothesis, the entire graph of the error curve is shifted to the left or right when the endpoints are moved accordingly.
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