Comparisons of experimental data with theory for the diffracted fields behind a parallel planar array of dielectric cylinders indicate the importance of iterative focusing in explaining field anomalies.
Comparisons of experimental data with theory for the diffracted fields behind a parallel planar array of dielectric cylinders indicate the importance of iterative focusing in explaining field anomalies.
Background: JAK inhibitors (JAKi) represent the latest development in the tackle to treat multiple inflammatory conditions. There is limited real-world data on their use. In 2022, the EMA Pharmacovigilance committee s...
Background: JAK inhibitors (JAKi) represent the latest development in the tackle to treat multiple inflammatory conditions. There is limited real-world data on their use. In 2022, the EMA Pharmacovigilance committee suggested that JAKi should only be used if alternative therapies are not available in patients over 65 years, smokers or those with cardiovascular or cancer risk factors. Objectives: To describe the demographics, duration of therapy and adverse events profile of patients prescribed JAKi at a large tertiary centre. Methods: The rheumatology database was reviewed to identify patients with past or current prescriptions of JAKi (Tofacitinib, Baricitinib, Filgotinib, Upadacitinib). Baseline data including age, gender, smoking status, ethnicity, co-morbidities, cardiovascular risk factors, rheumatic diagnosis, concomitant csDMARD use and prior biological therapies was collected. The duration of therapy on JAKi and reasons for stopping JAKi were identified. A Cox proportional hazard model was used to plot survival of drug therapy, by JAKi drug. Results: In total, 237 patients were prescribed a JAKi since 2017. The average age was 56.5, with a female predominance (n=195, 82%), and the majority had rheumatoid arthritis (Table 1). Baricitinib and Filgotinib represented the most commonly prescribed JAKi. About 16% of the cohort were using JAKi monotherapy (n=38). In those on combination therapy, methotrexate was the most commonly prescribed csDMARDs (n=82, 35%). Over 43% of patients had more than 1 prior biologic, with TNFi the most frequent (n=154, 65%). There were differences in the number of individuals with a cardiovascular risk factor, prior VTE and cancer diagnosis, between the four drug groups. The median duration of JAKi therapy was 2.3 years (IQR 1.0-3.9), with the lowest median duration seen with baricitinib (1.4, 0.9-3.7). One-third (n=79) of patients stopped JAKi therapy due to adverse events (n=35), primary failure (n=19) and secondary failure (n=22).
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