The deep integration of global economic and financial activities accelerates the information transmission across financial markets. The cross-market information has become a crucial factor to influence the stock marke...
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The deep integration of global economic and financial activities accelerates the information transmission across financial markets. The cross-market information has become a crucial factor to influence the stock market fluctuation. This paper investigates the explanatory power and impacting mechanism of cross-market information flow in the prediction of Chinese stock market volatility. The empirical results show that the cross-market information flow exhibits significant linear and nonlinear influences on Chinese stock market volatility, and it also appears termheterogeneous on the prediction accuracy, i.e., the cross-market information flow significantly contributes to medium-term and long-term prediction of Chinese stock market volatility, and the improvement of prediction accuracy is mainly due to nonlinear mechanism, whereas the crossmarket information flow performs less value for short-term volatility prediction.
Method for constant brake mean effective pressure air line operation outlined;curves presented showing engine brake horsepower required, plotted against true airspeed and altitude;rpm and manifold pressure plotted aga...
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Method for constant brake mean effective pressure air line operation outlined;curves presented showing engine brake horsepower required, plotted against true airspeed and altitude;rpm and manifold pressure plotted against brake horsepower and altitude;indicated air speed calibrated with altitude and true air speed;and fuel consumption. (see also Flight v 41 n 1730 Feb 19 1942 p 156-9)
Oldham Council was chosen to become one of 13 pilot sites leading the implementation of individual budgets. It is currently well advanced in introducing individual budgets, with over 1,000 people having received an in...
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Oldham Council was chosen to become one of 13 pilot sites leading the implementation of individual budgets. It is currently well advanced in introducing individual budgets, with over 1,000 people having received an indicative amount and over 500 people having agreed support plans and self-directing their support. In this paper, the author outlines the challenges that face local authorities in the implementation of individual budgets and raises questions about some longer-term impacts of them upon commissioning, social care services and performance management.
Anagrelide (BL-4162A, 6,7-dichloro-1,5-dihydroimidazo[2,1-6] quinazolin-2[3H]one monohydrochloride hydrate) is a potent and broad spectrum inhibitor of platelet aggregation. Prior studies showed that anagrelide inhibi...
Anagrelide (BL-4162A, 6,7-dichloro-1,5-dihydroimidazo[2,1-6] quinazolin-2[3H]one monohydrochloride hydrate) is a potent and broad spectrum inhibitor of platelet aggregation. Prior studies showed that anagrelide inhibited platelet cyclic AMP (cAMP) phosphodiesterase activity but did not appreciably elevate platelet cAMP levels. We examined the effects of anagrelide on washed human platelets and found that anagrelide caused significant elevation of cAMP levels. Anagrelide treatment also resulted in activation of the platelet cAMP-dependent protein kinase at anagrelide concentrations of 0.1 to 1 .mu.g/ml, which inhibited platelet aggregation but caused only small increases in platelet cAMP content. When whole platelets were incubated with radiolabeled phosphate, anagrelid increased phosphorylation of platelet proteins with relative molecular weights of 22, 26, 50 and 80 kilodaltons. The pattern of protein phosphorylation stimulated by anagrelide treatment was similar to that observed when the platelets were treated with forskolin. Anagrelide also inhibited the rise in intracellular Ca++ caused by thrombin, as measured using Fura-2-loaded platelets. The inhibition of increased intracellular Ca++ resulted from block of thrombin-induced mobilization of intracellular Ca++, as well as prevention of Ca++ influx through the plasma membrane. Anagrelide itself had no influence on inositol 1,4,5-trisphosphate-induced Caz5++ release from isolated platelet membrane vesicles. These studies suggest that anagrelide inhibits platelet phosphodiesterase activity in intact platelets resulting in an elevation of cAMP levels sufficient to activate the cAMP-dependent protein kinase and inhibit agonist-activated Ca++ fluxes.
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