Chronic obstructive pulmonary disease(COPD) is one of the most common pulmonary *** is evidence to suggest that dysbiosis of pulmonary microbiota participates in COPD *** Sanjie Formula(YS) is widely used to treat dis...
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Chronic obstructive pulmonary disease(COPD) is one of the most common pulmonary *** is evidence to suggest that dysbiosis of pulmonary microbiota participates in COPD *** Sanjie Formula(YS) is widely used to treat diseases in respiratory systems,yet its mechanisms are little *** the present study,the efficacy of YS was evaluated by analyzing its effects on the severity of pulmonary pathological damage,pulmonary function,pro-inflammation cytokines,the activation of nod-like receptor protein 3(NLRP3)/caspase-1/IL-1 β signaling pathway,and changes of lung *** improved animal behaviors,prevented declines in pulmonary ventilatory function and lung injury in a rat model of *** of YS significantly suppressed the release of proinflammatory cytokines and collagen deposition and downregulated NLRP3/caspase-1/IL-1 β signaling in *** changed the relative abundance of specific pulmonary microbiota and modulated bacterial flora in the rat *** results suggest that the effects of YS involved lung microbes and anti-inflammatory mechanisms.
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