The liver plays a key role in lipid metabolism as the hub of fatty acid synthesis and lipid circulation through lipoprotein *** an abundance of dietary fat intake,excessive fat accumulates in the blood, causing hyperl...
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The liver plays a key role in lipid metabolism as the hub of fatty acid synthesis and lipid circulation through lipoprotein *** an abundance of dietary fat intake,excessive fat accumulates in the blood, causing hyperlipidemia,and in the liver cells as lipid droplets,resulting in hepatic ***,we reported that in SRC-3-/- mice,the serum level of TC,TG and lipoprotein HDL were significantly lower than their wild type littermates under a normal *** diet induced obesity model,SRC-3-/- mice were protected from hyperlipidemia and fatty liver compared to SRC-3+/+ *** investigation revealed that the expression level of PPARα,a master gene governing lipid metabolism,was elevated while its negative regulator COUP-TFⅡwas decreased in livers of SRC-3-/- *** the molecular level,under all-trans retinoic acid treatment,SRC-3 interacted with retinoic receptor a and bound to -628/-448 region of the COUP-TFⅡpromoter to activate its expression ***,these findings suggest,for the first time,a crucial role of SRC-3 in lipid homeostasis.
目的检测单纯性肥胖及正常青少年血清内脂素水平，探讨其与年龄、体重指数（BMI）、脂联素、瘦素、血脂、血糖及胰岛素水平的关系。方法研究对象共148名，其中单纯性肥胖症青少年72例，正常对照76名。采用放射免疫分析法、酶法测定两组青少年的空腹血清内脂素、脂联素、瘦素、睾酮、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇（HDL-C）等。肥胖组青少年均做口服葡萄糖耐量试验（OGTr），计算胰岛素抵抗指数（HOMA—IR）、胰岛素敏感指数（ISI）和早期胰岛素分泌指数（EISI）。结果肥胖组血清内脂素水平显著高于正常对照组[（37．65±18．28 vs 29．35±12．10）μg/L，P〈0．01]。正常对照组血清内脂素水平与人体测量指数及脂质参数之间无任何相关性，而肥胖组血清内脂素与年龄、EISI和Tanner分期呈负相关，与血清HDL—C水平呈正相关。并且在校正年龄、性别、体重指数后，内脂素水平与年龄及HDL—C水平仍然呈显著相关（P〈0．05）。结论在中国青少年人群中，血清内脂素随年龄增长而下降，且可能参与体内HDL—C代谢的调控。
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