Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and is a leading cause of cancer ***,the pathophysiological mechanisms contributing to HCC are still largely *** data have demonstrated that ...
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Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and is a leading cause of cancer ***,the pathophysiological mechanisms contributing to HCC are still largely *** data have demonstrated that genetic alterations alone cannot account for the complexity of human carcinogenesis,but epigenetic changes,such as DNA methylation,histone modifications and microRNA expression,are also involved in this process.
Liver regeneration driven by hepatocyte proliferation is necessary for tissue repair and survival after acute liver injury,liver transplantation,and chronic hepatic *** a partial hepatectomy(PHx)in mice,a rapid induct...
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Liver regeneration driven by hepatocyte proliferation is necessary for tissue repair and survival after acute liver injury,liver transplantation,and chronic hepatic *** a partial hepatectomy(PHx)in mice,a rapid induction of proliferative factors activates quiescent hepatocytes and primes their subsequent *** this process,many transcription factors are activated and up-regulate a large number of proliferation-related target genes to repair the liver.c-Myc is a central transcription factor and is essential for total liver *** up-regulation of c-myc mRNA occurs 30 minutes after PHx and sharply increases after several ***,the mechanism of the fast up-regulation of c-myc in early liver regeneration remains *** this study,we reported for the first time that a c-myc-related positive feedback loop contributed to this phenomenon.A long noncoding RNA(lncRNA),H19,stabilized the c-myc mRNA by forming a H19-hnRNP U-myc complex and was transcriptionally up-regulated by c-myc in liver *** many microRNAs,which are a type of noncoding RNA,have been reported to control liver regeneration,H19 is the first lncRNA that is involved in liver *** also found that H19 promotes an epithelial-to-mesenchymal transition(EMT)in liver cells during ***:lncRNA-H19 promotes hepatocyte proliferation and EMT by stabilizing c-myc mRNA in early liver ***,the existence of a c-myc-related positive feedback loop augmented the effect of c-myc for a short time period during early liver regeneration.
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