临床相关剂量的抗癌药物均可以导致恶性肿瘤及细胞系发生细胞衰老和凋亡。衰老逃逸是细胞存活和耐药的重要机制,通过逃避凋亡和死亡,细胞重新进入到细胞周期的S期。近年来的研究表明多倍体肿瘤巨细胞(polyploid giant cancer cells,PGCC...
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临床相关剂量的抗癌药物均可以导致恶性肿瘤及细胞系发生细胞衰老和凋亡。衰老逃逸是细胞存活和耐药的重要机制,通过逃避凋亡和死亡,细胞重新进入到细胞周期的S期。近年来的研究表明多倍体肿瘤巨细胞(polyploid giant cancer cells,PGCC)有助于肿瘤的发生、侵袭、转移和治疗抵抗,这些PGCC的形成是肿瘤细胞发生衰老逃逸的前提,通过去多倍体化的方式,它们能够产生具有增殖活性的子代细胞,进而逃脱细胞衰老。本文就PGCC与细胞衰老和治疗抵抗之间的相关研究进展以及靶向PGCC的治疗策略进行概述,为探索致命性癌症的治疗干预提供一个全新的模式。
提高课程思政教学效果,必须要建立健全的课程思政建设质量评价体系,目前对于课程思政教学效果评价的研究相对较少,亟须在深入把握思政课程教学评价特殊性的前提下,构建思政课立体化教学评价体系。文章梳理了基于CIPP、AHP (AMP)-FCE和OBE模型和理念构建的三种主要的课程思政教学评价体系及其应用情况,以期为将来更切实推进课程思政教学评价体系的建设和实施提供一定参考。To improve the effectiveness of ideological and political education in courses, it is necessary to establish a sound evaluation system for the quality of ideological and political education in courses. Currently, there is relatively little research on the evaluation of the effectiveness of ideological and political education in courses. It is urgent to construct a three-dimensional teaching evaluation system for ideological and political education, based on a deep understanding of the special characteristics of ideological and political education evaluation. This article summarizes three main evaluation systems for ideological and political education in courses based on CIPP, AHP (AMP)-FCE, and OBE models and concepts, as well as their applications, in order to provide some reference for more effectively promoting the construction and implementation of the evaluation system for ideological and political education in courses in the future.
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