Evidences from both clinical and experimental researches indicate that the immune-depression interactions play pivotal roles in the pathophysiology of depression.A multi-protein complex of the innate immune system,the...
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Evidences from both clinical and experimental researches indicate that the immune-depression interactions play pivotal roles in the pathophysiology of depression.A multi-protein complex of the innate immune system,the NLRP3 inflammasome regulates cleavage and secretion of pro-inflammatory cytokines interleukin-1βand *** can detect a bunch of pathogen-associated molecule patterns and damage-associated molecule patterns and lead to a series of immune-inflammatory *** explore the role of inflammasome activation in depression and some of its underlying biological mechanisms,we established a depression mouse model with unpredictable chronic mild stress(CMS).Mice subjected to CMS for 4 weeks displayed depressive-like symptoms,including adrenocortical activation,decreased sucrose preference and increased immobility time,concomitantly with elevated IL-1βprotein levels in serum and ***,there were significantly higher active IL-1βlevels and increased activation and expression of the NLRP3 inflammasome in hippocampi of CMS exposed *** with NLRP3 inflammasome inhibitor VX-765 decreased IL-1βlevels in serum and hippocampi,and significantly abrogated the depressive-like behaviors induced by *** data suggest that the NLRP3 inflammasome is a central mediator between immune activation and ***,procedures target the NLRP3 inflammasome may have promising effects in depression therapies.
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