Recurrent genome copy number aberrations are known to be a common feature of many cancers,including Hepatocellular carcinoma (HCC), and their analysis is expected to reveal genes involved in ***, in many regions with ...
Recurrent genome copy number aberrations are known to be a common feature of many cancers,including Hepatocellular carcinoma (HCC), and their analysis is expected to reveal genes involved in ***, in many regions with high frequency copy number variations (CNVs), the aberrantly expressed protein-coding genes is unable to make a sense,which suggest that the mechanisms underlying carcinogenesis may be partly contributed to the differently expression of long non-coding RNA (lncRNAs).Then an overlap analysis of lncRNAs expression microarray and genome copy number variations data in HCC was carried out and we identified a set of lncRNAs whose expression levels correlated with common chromosomal aberrations, in which lncRNA-PRAL is consistently decreased with a significant correlation with the copy number *** found that lncRNA-PRAL could promote the tumor cell apoptosis and suppress the progress of carcinogenesis in ***,lncRNA-PRAL can participate in HSP90-p53 protein complex formation to help facilitate the nuclear transportation of p53.
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