Total and free plasma tryptophan and other biochemical parameters were tested in 20 normal individuals as well as 52 patients with liver diseases, including 20 patients with hepatic coma. In addition, 12 pigs with ind...
Total and free plasma tryptophan and other biochemical parameters were tested in 20 normal individuals as well as 52 patients with liver diseases, including 20 patients with hepatic coma. In addition, 12 pigs with induced acute is-chaemic hepatic failure were also experimentally studied. The results revealed that the plasma tryptophan levels were closely correlated with the presence, grade and evolution of hepatic coma. In hepatic coma the free plasma free tryptophan level was more significantly elevated than total tryptophan level. The molar ratios of plasma free tryptophan to BCAA, BCAA + AAA + Met and total tryptophan were correlated with the presence of hepatic coma. Furthermore, the clinical investigation showed that plasma free tryptophan and total tryptophan correlated significantly with serum total bilirubin and prothrombin time respectively. The ratio of free tryptophan /total tryptophan also correlated significantly with prothrombin time. The authors point out that the value of plasma tryptophan (mainly free tryptophan) might reflect the parenchymal function of liver and the prognosis of the disease.
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