Objective To analyze heart rate variability (HRV)and its changes with thyroxine treatment in patients with hypothyroidism. Methods HRV was analyzed using 24-hour electrocardiographic recording in 38 patients with hy...
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Objective To analyze heart rate variability (HRV)and its changes with thyroxine treatment in patients with hypothyroidism. Methods HRV was analyzed using 24-hour electrocardiographic recording in 38 patients with hypothyroidism and 21 normal controls. The changes in HRV were evaluated for the 18 hypothyroid patients after 3 months of thyroxine *** The time domain measurements of HRV in hypothyroid patients were much lower than those in the control group. As to HRV frequency domain, the high frequency power was significantly higher, but the ratio of low frequency power to frequency power for hypothyroid patients was lower than in the controls. These abnormal changes of HRV measurements in hypothyroid patients were improved after treatment with thyroxine and were associated with recovery of serum concentrations of FT3 and FT4. Conclusions Patients with hypothyroidism often have autonomic neuropathies with a higher level of vagal tone. These abnormalities could be partly improved by thyoxine therapy.
治疗药物浓度监测（therapeutic drug monitoring，TDM）为个体化抗肿瘤治疗提供了便利。阿糖胞苷（cytosine—arabinoside，Ara—C）是临床治疗白血病最常用的药物之一，其在细胞内产生的阿糖尿苷（uridine—arabinoside，Ara—U）为...
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治疗药物浓度监测（therapeutic drug monitoring，TDM）为个体化抗肿瘤治疗提供了便利。阿糖胞苷（cytosine—arabinoside，Ara—C）是临床治疗白血病最常用的药物之一，其在细胞内产生的阿糖尿苷（uridine—arabinoside，Ara—U）为无效代谢物。本文设计用Ara—U／Ara—C浓度的比值，作为Ara—C耐药性指标，若患者体内的Am—U与Ara—C比值高，就认为该患者对Ara—C耐药；反之则为敏感。
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