Recently,a major challenge in nanomedicine for cancer drug delivery is to engineer nanostructures which can efficiently load drugs with high concentration,cross the cell membrane,and controllably release the cargos at...
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Recently,a major challenge in nanomedicine for cancer drug delivery is to engineer nanostructures which can efficiently load drugs with high concentration,cross the cell membrane,and controllably release the cargos at the target ***,we report a classes of smart nanocarriers based on mesoporous silica nanoparticles（MSNs） and PAMAM to achieving high targeting specificity and delivery efficiency,avoiding nonspecific binding and entrapment by the body's *** is studied,silica-based DDS suffer from poor pharmacokinetics,short blood circulation half-lives,and accumulation in capillary ***,we modified the MSNs with polyacrylic acid（PAA） shorted as PAA-MSNs,realized pH-responsive controlled release in cancer *** further improve water suspensibility,decreased nonspecific protein binding and enhance specific affinity,we coated PAA-MSNs with a glioma targeting peptides（Angiopep-2） modified lipid *** smart nanocarriers deliver the Arsenic trioxide（ATO,AsO） to the targeting region successfully and show stronger antitumor activity and lower toxicity than *** another,as to PAMAM-based DDS,we constructed different PEGylation degree of G5-PAMAM which were also conjugated the targeting ligand of angiopep-2（aniopep-2-PEG-PAMAM）,besides,borneol and folic acid were also used to modified PAMAM,so that another smart nanocairrer（FA-BO-PAMAM） was *** nanocarriers was proved to decrease the cytotoxicity of PAMAM and increase the transport ratio of DOX across the BBB and then to target the brain glioma,and displayed higher cell uptake,stronger growth inhibition of glioma cells,better curing effect on glioma,and improved survival time of C6 cells-implanted *** results show that these smart nanocarriers are promising drug delivery system for rumor treatment.
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