Objective To explore the ability of texture analysis of gadoxetic acid-enhanced magnetic resonance imaging(MRI) T1 mapping images, as well as T1-weighted(T1 W), T2-weighted(T2 W) and apparent diffusion coefficient(ADC...
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Objective To explore the ability of texture analysis of gadoxetic acid-enhanced magnetic resonance imaging(MRI) T1 mapping images, as well as T1-weighted(T1 W), T2-weighted(T2 W) and apparent diffusion coefficient(ADC) maps for distinguishing between varying degrees of hepatic fibrosis in an experimental rat *** Liver fibrosis in rats was induced by carbon tetrachloride intraperitoneal injection for 4–12 weeks(n = 30). In the control group(n = 10) normal saline was applied. The MRI protocol contained T2 W, diffusion weighted imaging, pre-and post-contrast image series of T1 W and T1 mapping images. METAVIR score was used to grade liver fibrosis as normal(F0), mild fibrosis(F1–2), and advanced fibrosis(F3–4). Texture parameters including mean gray-level intensity(Mean), standard deviation(SD), Entropy, mean of positive pixels(MPP), Skewness, and Kurtosis were obtained. Nonparametric Mann-Whitney U test was used to compare the average value of each texture parameter in each sequence for assessing the difference between F0 and F≥1 as well as F0–2 and F3–4. Receiver operating characteristic(ROC) curves were obtained to assess the diagnosing accuracy of the parameters for differentiating no liver fibrosis from liver fibrosis and rats with liver fibrosis grading F0–2 from those with grading F3–4. The area under ROC curve(AUC) was calculated to evaluate the diagnostic efficiency of texture *** Finally, 20 rats completed MR T1 mapping image scan. The pathologic staging of these 20 rats was no fibrosis(F0, n = 6), mild fibrosis(F1–2, n = 5) and advanced fibrosis(F3–4, n = 9). On pre-contrast T1 mapping image, Entropy was seen to be statistically significant higher in the F≥1 group than that in the F0 group at each spatial scaling factor(SSF) setting(P = 0.015, 0.015, 0.015, 0.013, 0.015 and 0.018 respectively to SSF = 0, 2, 3, 4,5, 6), and Mean of the F≥1 rats was statistically significant higher than that of the F0 rats at SSF 4, 5, 6(P = 0.004, 0.0
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