Objective To clarify the role of sexual related Y (SRY) gene detection in the diagnosis of gonadal *** Sixteen cases of gonadal dysgenesis were included in this study: 5 with androgen insensitivity syndrome, 1 with ...
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Objective To clarify the role of sexual related Y (SRY) gene detection in the diagnosis of gonadal *** Sixteen cases of gonadal dysgenesis were included in this study: 5 with androgen insensitivity syndrome, 1 with 17-α-hydroxylase deficiency, 4 with true hermaphrodite, 2 with 45,X/46,XY gonadal dysgenesis, 1 with 45,X gonadal dysgenesis, 1 with XY pure gonadal dysgenesis, 1 with testicular regression, and 1 XY female who gave birth to a normal baby. SRY gene was detected by using polymerase chain reaction (PCR) in blood and gonad samples and by direct sequencing of the SRY *** Among the 16 cases, 15 were blood SRY positive, among which 13 (86.7%) showed the presence of testicular tissue, and 2 showed ovaries without testicular tissue. One SRY negative case showed the presence of testicular tissue. In 3 cases, SRY detection in gonadal tissue correlated with pathological findings but not with blood karyotype. The correlation between peripheral blood SRY and the pathology of the gonads was 81.25% and the correlation between the presence of peripheral blood Y chromosome and pathology of the gonads was 68.75%. Sequencing of the SRY motif in an XY female who gave birth to a normal baby showed no *** SRY detection is more sensitive and specific than blood karyotype in the prediction of the presence of testicular tissue. Peripheral blood karyotype does not necessarily reflect gonadal type. There may be testicular related factors other than the SRY gene.
子宫内膜异位症(内异症)有临床病变的广泛性和病理表现的多形性.身体的各个部位,多数可发生内异症,依次是卵巢(44.0%)、直肠子宫陷凹(34.0%)、盆腔腹膜、腹壁切口、膀胱壁、子宫颈、输卵管、肠壁、外阴、阴道及其他部位.早于1920年,美国医学会在《外科档案》杂志(Archives of Surgery)上发表的Cullen提出的内异症的部位(图1,引自Endometriosis advanced management and surgical techniques. 1995. 10.),已表明对内异症有了较明确的认识.
妊娠性滋养细胞疾病(gestational trophoblastic disease,GTD),包括葡萄胎(hydatidifo r m moles,HM)、侵蚀性葡萄胎(invasive moles,IM)、绒毛膜癌(choriocarcinoma,CC)和胎盘部位滋养细胞肿瘤(placenta site trophoblastic tumors,PST...
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妊娠性滋养细胞疾病(gestational trophoblastic disease,GTD),包括葡萄胎(hydatidifo r m moles,HM)、侵蚀性葡萄胎(invasive moles,IM)、绒毛膜癌(choriocarcinoma,CC)和胎盘部位滋养细胞肿瘤(placenta site trophoblastic tumors,PSTT).侵蚀性葡萄胎几乎10 0%来源于葡萄胎,妊娠性绒毛膜癌和胎盘部位滋养细胞肿瘤既可来源于葡萄胎,也可来自足月产、早产及各类型的流产.继发于葡萄胎的绒毛膜癌和胎盘部位滋养细胞肿瘤,分别为50 %和15%～20%.多数作者赞同上述前3种为同一疾病的不同阶段.若能在葡萄胎阶段进行正确处理,则侵蚀性葡萄胎和绒毛膜癌的发病率也可下降.因此,对葡萄胎的发病因素进行了较多的研究,但至今仍未明确.限于篇幅,现就近年来有关葡萄胎的病因研究予以简述.
Interventional radiology is now widely applied in the diagnosis and treatment of obstetrical and gynecological disease Despite its value in the diagnosis of gynecological malignancies, selective/superselective angiogr...
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Interventional radiology is now widely applied in the diagnosis and treatment of obstetrical and gynecological disease Despite its value in the diagnosis of gynecological malignancies, selective/superselective angiography is also helpful in the clinical staging Regional arterial infusion chemotherapy can improve the prognosis of the advanced cancer cases and can improve the operability as the preoperative adjuvant chemotherapy For the treatment of pelvic bleeding, interventional radiology provides a more rapid and less invasive way than the traditional
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