Alzheimer’s disease is a progressive neurodegenerative disorder characterized by cognitive decline and dementia The typical neuropathological changes are extracellular amyloid plaques and intracellular neurofibrillar...
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Alzheimer’s disease is a progressive neurodegenerative disorder characterized by cognitive decline and dementia The typical neuropathological changes are extracellular amyloid plaques and intracellular neurofibrillary tangles of patients’ brain The main component of the former is β amyloid peptide degraded abnormally from β amyloid precursor protein, the latter is the aggregation of Tau protein which is phosphorylated highly There are some hypotheses about its pathogenesis at every aspect from cellular to molecular level Mitochondria, which acts as a half autonomous organella and a cytological energy producing factory, can form free radical and produce oxidative stress, also it can devastate intracellular calcium homeostasis, induce cell apoptosis and accelerate aging. Most of the variation seem to be arisen from the mutation of mitochondrial genetic material As a result, there are also many researches about mitochondria and its probable roles in Alzheimer’s disease Here we summerized some advances in those
Apolipoprotein A Ⅰ, the major protein component of the HDL, exerts its important function during modulating the metabolism of lipids in the plasma. Animal experiments have established that high concentration of the a...
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Apolipoprotein A Ⅰ, the major protein component of the HDL, exerts its important function during modulating the metabolism of lipids in the plasma. Animal experiments have established that high concentration of the apo A Ⅰ not only inhibits the initiation and progression of atherosclerosis, but also makes the preexisting atherosclerotic lesions regress. The most accepted mechanism is reverse cholesterol transport(RCT). It may become a new non traumatic therapy that the atherosclerosis is prevented and treated by the purified or recombinant human apolipoprotein A Ⅰ.
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