To reveal the role of platelet-derived growth factor-α and β receptor in hypoxic pulmonary vascular remodeling. We investlgated the changes of PDGF-α and β receptor gene expression under hypoxic condition. Methods...
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To reveal the role of platelet-derived growth factor-α and β receptor in hypoxic pulmonary vascular remodeling. We investlgated the changes of PDGF-α and β receptor gene expression under hypoxic condition. Methods Hypoxic pulmonary hypertension rats model was reproduced by normobaric hypoxia. Changes of pulmonary PDGF-α and β mRNA were examined by in situ hybridization. Results The PDGF-α receptor mRNA of the hypoxia group (3 days) declined to 86% compared with that of the control group, and shooting up to 217% of control at day 7, then sustained at 224% until day 14. (all P<0.001). PDGF-β receptor mRNA markedly increased at day 3 after hypoxia and maintained this increasing tendency consistently. Its top was 164% at day 14 (P<0. 001). The growth inhibitor, heparin had alleviated the increases of both rat pulmonary arterial pressure and PDGF receptor gene expression. Conclusion Hypoxia led to the increase of PDGF-α and β receptor gene expression in pulmonary vascular endothelial and smooth muscle cells, and might be involved in hypoxic pulmonary vascular remodeling.
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