The current epidemiological studies have reported that short-term or long-term exposure to atmospheric fine particulate matter(PM) can cause adverse health effects of multiple systems in human being,including signific...
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The current epidemiological studies have reported that short-term or long-term exposure to atmospheric fine particulate matter(PM) can cause adverse health effects of multiple systems in human being,including significant reducing the Life Expectancy（LE）of human population,but the impact and its regulatory mechanism on healthspan in model organisms and human Health Adjusted Life Expectancy（HALE） are all unknown,which deserves further *** Caenorhabditis elegans（*** or "nematode"） has been recognized as a powerful model organism on studying lifespan,for elucidating conserved pathways and processes relevant to human *** this study,water-soluble components of outdoor PM samples were collected in north *** on *** in vivo model,the toxic effects（acute toxicity,growth and development,lifespan and healthspan,etc.） of PM were detected,and the mechanisms were studied *** results indicated that PM could induce growth and development toxicity by alteration the body length and width of nematodes,shorten nematodes' lifespan and *** mechanism might be involve with the insulin/insulin-like factor-1 signaling pathway（IIS pathway）,lipid metabolism and transport disorders,which under further exploration
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