Type II DNA topoisomerases（Tops）are ATP-dependent enzymes that catalyze topological transformations of genomic DNA by the transport of one DNA double helix through *** mammals,there are 2 isoforms of DNA Top II, ter...
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Type II DNA topoisomerases（Tops）are ATP-dependent enzymes that catalyze topological transformations of genomic DNA by the transport of one DNA double helix through *** mammals,there are 2 isoforms of DNA Top II, termed Top IIβ and Top IIβ.The IIβ isoform is abundantly expressed in cells that have undergone the final cell division and are committed to differentiation into neuronal *** recent years,there have been accumulating studies showing the significant role of Top IIβ in neuronal development through regulating expression of certain genes in cells committed to the neuronal fate after the final *** genes are involved in the processes of neuronal differentiation,migration,axon guidance and so *** present review mainly focused on the research progress on the role of Top IIβ in neuronal development over the recent decades.
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