Psychotic major depression （ PMD ）, which responds poorly to tricyclie anti-depressants, is a distinct syndrome of depression. Hypercortisolemia （cortisone hyperseeretion ）, a biological abnormality existing in ma...
详细信息
Psychotic major depression （ PMD ）, which responds poorly to tricyclie anti-depressants, is a distinct syndrome of depression. Hypercortisolemia （cortisone hyperseeretion ）, a biological abnormality existing in many patients with PMD, has led to various theoretical and empirical rationales for the potential therapeutic use of ami-glueoeortieoid agents in the treatlnent of depression. Most available anti-depressant medications today increase braiu levels of glucocortieoid receptor （GR）, rendering individuals more sensitive to corticosteroid negative feedback regulated by hypothalamic-pituitaly-adrenal （HPA） axis. Recently, several studies have assessed the behavioral effects of direct pharmacological lowering of cortisol levels in patients with PMD using GR antagonists, such as RU486 （ mifepristone ）
暂无评论