Alzheimer’s disease ranks the first cause for senile *** amyloid cascade is proposed to contribute to the pathogenesis of this *** this cascade,amyloid β peptide（Aβ）is produced through a sequential cleavage of am...
详细信息
Alzheimer’s disease ranks the first cause for senile *** amyloid cascade is proposed to contribute to the pathogenesis of this *** this cascade,amyloid β peptide（Aβ）is produced through a sequential cleavage of amyloid precursor protein（APP）by β and γ secretases,while its cleavage by α secretase precludes Aβ production and generates neurotrophic sAPPα.Thus,enhancing α secretase activity or suppressing β and γ cleavage may reduce Aβ formation and ameliorate the pathological process of the *** regulatory mechanisms of APP cleavage have been established. The present review mainly summarizes the signaling pathways pertinent to the regulation of APP β cleavage.
暂无评论