Objective It has been shown that there are extensive interactions between the central nervous system and the immune *** present study focused on the effects of lipopolysaccharide（LPS）on memory retrieval,to explore t...
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Objective It has been shown that there are extensive interactions between the central nervous system and the immune *** present study focused on the effects of lipopolysaccharide（LPS）on memory retrieval,to explore the interaction between immune activation and *** C57BL/6J mice（8 weeks old）were first trained in the Morris water maze to reach asymptotic *** mice were tested 24 h after the last training session and LPS was administered（1.25 mg/kg,i.p.）4 h prior to the *** retrieval of spatial memory was tested by probe trial,and the time spent in the target quadrant and the number of platform location crosses were *** was performed to detect interleukin-1β（IL-1β）protein level in the hippocampus of mice tested in the water *** Although LPS induced overt sickness behavior and a significant increase in the level of IL-1β in the hippocampus of mice,there was no significant difference in the time spent in the target quadrant or in the number of platform location crosses between LPS-treated and control groups in the probe trial *** Immune activation induced by LPS does not impair the retrieval of spatial memory.
Interleukin-1β（IL-1β）is one of the first cytokines ever *** has long been recognized to play an important role in mediating inflammation and orchestrating the physiological and behavioral adjustments that occur du...
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Interleukin-1β（IL-1β）is one of the first cytokines ever *** has long been recognized to play an important role in mediating inflammation and orchestrating the physiological and behavioral adjustments that occur during sickness. Recently,accumulating evidence has indicated that IL-1β also adversely affects cognitive ***,there are also some reports showing no effects or even beneficial effects of IL-1β on learning and *** relationship between IL-1β and cognitive impairment has not been clearly *** we reviewed the evidence of both negative and positive effects of IL-1β on learning and memory,and the key factors that may affect the effects of IL-1β on learning and memory were discussed.
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