Cancer is the second leading disease causing human ***-clinical in vivo studies are essential for translating in vitro laboratory research results into the ***,including the mouse and rat,have been widely used for pre...
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Cancer is the second leading disease causing human ***-clinical in vivo studies are essential for translating in vitro laboratory research results into the ***,including the mouse and rat,have been widely used for pre-clinical studies due to their small size,clear genetic backgrounds,rapid propagation,and mature transgenic ***,because rodents are evolutionarily distinct from humans,many pre-clinical research results using rodent models cannot be reproduced in the ***-human primates（NHPs） may be better animal models than rodents for human cancer research because NHPs and humans share greater similarity in regards to their genetic evolution,immune system,physiology and *** article reviews the latest progress of cancer research in NHPs by focusing on the carcinogenesis of different NHPs induced by chemical and biological ***,future research directions for the use of NHPs in cancer research are discussed.
Due to their special phylogenetic position in the Euarchontoglires and close affinity to primates,tree shrews have been proposed as an alternative experimental animal to primates in biomedical ***,the population genet...
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Due to their special phylogenetic position in the Euarchontoglires and close affinity to primates,tree shrews have been proposed as an alternative experimental animal to primates in biomedical ***,the population genetic structure of tree shrews has largely remained unknown and this has hindered the development of tree shrew breeding and *** we sampled 80 Chinese tree shrews（Tupaia belangeri chinensis） in Kunming,China,and analyzed partial mtDNA control region sequence *** on our samples and two published sequences from northern tree shrews（***）,we identified 29 substitutions in the mtDNA control region fragment（～ 604 bp） across 82 individuals and defined 13 *** samples were selected for sequencing of the cytochrome b（Cyt b;1134 bp） gene based on control region sequence variation and were analyzed in combination with 34 published sequences to solidify the phylogenetic pattern obtained from control region ***,tree shrews from Kunming have high genetic diversity and present a remarkable long genetic distance to the two reported northern tree shrews outside *** results provide some caution when using tree shrews to establish animal models because of this apparent genetic *** addition,the high genetic diversity of Chinese tree shrews inhabiting Kunming suggests that systematic genetic investigations should be conducted before establishing an inbred strain for medical and biological research.
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