Animal models are essential for the development of new anti-infectious *** some bacterial infection models have been established in rodents,small primate models are ***,we report on two bacterial infection models esta...
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Animal models are essential for the development of new anti-infectious *** some bacterial infection models have been established in rodents,small primate models are ***,we report on two bacterial infection models established in tree shrew（Tupaia belangeri chinensis）.A burnt skin infection model was induced by dropping 5×106 CFU of Staphylococcus aureus on the surface of a wound after a third degree *** dose of *** caused persistent infection for 7 days and obvious inflammatory response was observed 4 days after inoculation.A Dacron graft infection model,2×106 CFU of Pseudomonas aeruginosa also caused persistent infection for 6 days,with large amounts of pus observed 3 days after *** models were used to evaluate the efficacy of levofloxacin（LEV） and cefoperazone（CPZ）,which reduced the viable bacteria in skin to 4log10 and 5log10 CFU/100 mg tissue,*** number of bacteria in graft was significantly reduced by 4log10 CFU/mL treatment compared to the untreated group（P0.05）.These results suggest that two bacterial infection models were successfully established in tree shrew using *** and *** addition,tree shrew was susceptible to *** and ***,thus making it an ideal bacterial infection animal model for the evaluation of new antimicrobials.
Recent genome studies indicate that tree shrew is in the order or a closest sister of primates,and thus may be one of the best animals to model human *** this paper,we report on a social defeat model of depression in ...
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Recent genome studies indicate that tree shrew is in the order or a closest sister of primates,and thus may be one of the best animals to model human *** this paper,we report on a social defeat model of depression in tree shrew（Tupaia belangeri chinensis）.Two male tree shrews were housed in a pair-cage consisting of two independent cages separated by a wire mesh partition with a door connecting the two *** one week adaptation,the connecting door was opened and a brief fighting occurs between the two male tree shrews and this social conflict session consisted of 1 h direct conflict（fighting） and 23 h indirect influence（***,visual cues） per day for 21 *** defeated tree shrew was considered the *** with na？ve animals,subordinate tree shrews at the final week of social conflict session showed alterations in body weight,locomotion,avoidance behavior and urinary cortisol ***,these alterations persisted for over two *** also report on a novel captive conditioning model of learning and memory in tree *** automatic trapping cage was placed in a small closed room with a freely-moving tree *** the first four trials,the tree shrew was not trapped when it entered the cage and ate the bait apple,but it was trapped and kept in the cage for 1 h on the fifth *** was defined as the time between release of the tree shrew and when it entered the captive *** during the five trials indicated adaptation.A test trial 24 h later was used to measure whether the one-trial trapping during the fifth trial could form captive *** shrews showed much longer trapping latencies in the test trial than the adaptation *** N-methyl-d-aspartate（NMDA） receptor antagonist MK-801（0.2 mg/kg,i.p.）,known to prevent the formation of memory,did not affect latencies in the adaptation trails,but did block captive memory as it led to much shorter trapping latencies compared to saline treatment in the test tr
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