Krüpple-like factor 5(KLF5) is required for the development of the embryo and multiple organs,such as the lung and ***5 plays a pro-proliferative and oncogenic role in multiple carcinomas,including breast ***,the...
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Krüpple-like factor 5(KLF5) is required for the development of the embryo and multiple organs,such as the lung and ***5 plays a pro-proliferative and oncogenic role in multiple carcinomas,including breast ***,the role of Klf5 in mammary gland oncogenesis has not been fully *** showed that KLF5 promotes mammary epithelial cell proliferation,adhesion,migration,survival,and stem cell maintenance,at least partially,by directly promoting the transcription of TNFAIP2 and Integrin *** identified several small molecule compounds,including mifepristone,metformin,Mithramycin A and JQ1,which target KLF5 and suppress breast cancer cell growth and *** findings revealed that KLF5 is required for breast cancer development,and could serve as a therapeutic target for breast cancer treatment.
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