In the present experiment, Pavlovian fear conditioning was adopted to study the effects of different early rearing environments on fear conditioning in adult rats. Weaned rats were reared in three manipulable environm...
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In the present experiment, Pavlovian fear conditioning was adopted to study the effects of different early rearing environments on fear conditioning in adult rats. Weaned rats were reared in three manipulable environments （enriched, social and isolated conditions）. After 8 weeks, fear conditioning （characterized by percentage of freezing） was observed and analyzed, and rats＇ weight, locomoter activity and foot-shock sensitivity were operated too. The results showed that： （1） Compared with control group, the level of conditioned fear was significantly increased in enriched group, but significantly decreased in isolated group; （2） Enriched and isolated conditions influenced rat＇s weight significantly; （3） Different rearing conditions have no effect on locomoter activity and foot-shock sensitivity. These results indicated that early enriched condition could improve the tone-evoked fear conditioning response, while isolated condition impaired the response.
条件化位置偏好(conditioned place preference,CPP),常用于研究药物成瘾的相关记忆。这里主要综述了一些药物对CPP的影响。神经肽S,神经肽FF,肌肽,孤啡肽,α-2受体激动剂,L-左旋千金藤啶碱,东莨菪碱,丙戊酸钠,巴氯芬对吗啡CPP有抑制效...
详细信息
条件化位置偏好(conditioned place preference,CPP),常用于研究药物成瘾的相关记忆。这里主要综述了一些药物对CPP的影响。神经肽S,神经肽FF,肌肽,孤啡肽,α-2受体激动剂,L-左旋千金藤啶碱,东莨菪碱,丙戊酸钠,巴氯芬对吗啡CPP有抑制效应;聚肌胞苷酸,氟伏沙明和金刚烷胺能增强吗啡CPP;阿坎酸能抑制乙醇和某些类别的滥用药物的条件化奖赏效应,但不影响吗啡引起的条件化奖赏效应;褪黑激素逆转吗啡诱导的奖赏效应;人重组干扰素-α导致吗啡CPP的恢复。
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