The present study aimed at studying the characteristics of tissue distribution and excretion of scopoletin,a coumarin compound,in Sprague-Dawley *** was orally administered at a dose of 50 mg/kg,and the concentrations...
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The present study aimed at studying the characteristics of tissue distribution and excretion of scopoletin,a coumarin compound,in Sprague-Dawley *** was orally administered at a dose of 50 mg/kg,and the concentrations in heart,liver,spleen,lung,kidney,muscle,fat,brain,testis,uterus,stomach and small intestine were determined at 5,15,30,60,120,240 min post-dose,*** was shown that scopoletin was widely distributed into various tissues and reached the maximal concentrations in most tissues at 15 min post-dose,and the levels in liver,kidney,stomach and small intestine were relatively ***,the excretions of scopoletin in bile,urine and feces were only 0.032%,3.752% and 0.784%,respectively,suggesting that scopoletin was mainly eliminated by metabolism rather than excretion as parent drug.
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