A central component of fish growth coordination is the Growth hormone-Insulin-like Growth Factor-Ⅰ(GH-IGF-Ⅰ) *** GH-IGFⅠ axis begins with GH production in the pituitary gland under the control of multiple hypothala...
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A central component of fish growth coordination is the Growth hormone-Insulin-like Growth Factor-Ⅰ(GH-IGF-Ⅰ) *** GH-IGFⅠ axis begins with GH production in the pituitary gland under the control of multiple hypothalamic hormones,including somatostatin(SS).SS have been proved to possess a variety of biological functions with widely distribution in the central nervous system and peripheral *** plays roles in the physiological process of the central nervous system,modulating growth,development and metabolism *** results on mammalian SS have been applied to produce new *** on fish somatostatin have lasted for over 25 years,and it has received more and more *** is an important animal model and one of the important protein source of human,research on fish SS can help to understand the physiology roles of SS and to regulate fish growth and other physiologic *** SS exists as two predominant biologically active forms, SS14 peptide and its N-terminal extensions of 14 amino acids,*** SS14 and SS28 are encoded by a common gene and processed from a single precursor,***14 is highly conserved in all known vertebrate species,including several mammalian species,chicken,frog and fishes,with the same amino acid *** addition to having PSSI,Fish possess one or two other different forms of somatostatin(SS),PSSⅡ and PSSⅢ.The PSSⅡ molecule is thought to be processed to a large form of SS(SS28 or SS25) with [Tyr7,Gly10]-SS14 at its C-terminus,while the PSSⅢ would produce a SS14 *** the three types of PSS genes had been cloned both in goldfish and Orange-spotted *** are widely distributed throughout the central nervous system(CNS) and peripheral tissues. PSS are differentially expressed,both in terms of the distribution among tissues and in terms of the relative abundance within a *** exerts diverse inhibitory actions through binding to specific membrane-bound G-protein-coupled r
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