辅助基因调控(agr)群体感应系统通过调控毒力因子及生物被膜形成等影响金黄色葡萄球菌毒力的表达。agr的信号传导主要依赖于自诱导信号肽(AIP)与AgrC结合后激活AgrA,而后直接由AgrA或转录后调节因子RNAIII作用于下游靶基因调控金黄色葡萄球菌的毒力因子。本综述主要讲述了AIP与AgrC结合以及AgrA作用于下游靶基因的机制。讨论了agr阴性突变菌株感染对临床患者的影响,还讨论了多种毒力调控基因与agr共同作用调节金葡菌毒力的复杂网络。Accessory gene regulator (agr) quorum sensing network affects the expression of Staphylococcus aureus virulence by regulating virulence factors and biofilm formation. The signal transduction of agr mainly depends on the activation of AgrA after the binding of AIP with AgrC, and then the direct action of AgrA or the post-transcriptional regulatory factor RNAIII on the downstream target gene to regulate the virulence factors of Staphylococcus aureus. This review mainly describes the mechanism of AIP binding to AgrC and AgrA acting on downstream target genes. The effects of agr negative mutant strains on clinical patients were discussed, and the complex network of virulence regulation genes and agr regulating Staphylococcus aureus was discussed.
迄今为止,术后恶心呕吐(postoperative nausea and vomiting, PONV)仍然是围术期间严重的并发症之一,它增加了患者手术切口破裂,出血的风险并可能导致吸入性肺炎,电解质紊乱,脱水等不良事件的发生,增加了患者的住院时间以及费用,在一定...
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迄今为止,术后恶心呕吐(postoperative nausea and vomiting, PONV)仍然是围术期间严重的并发症之一,它增加了患者手术切口破裂,出血的风险并可能导致吸入性肺炎,电解质紊乱,脱水等不良事件的发生,增加了患者的住院时间以及费用,在一定程度上影响了患者术后的生活品质。预防术后恶心呕吐仍然是临床上热议的话题之一,特别是预防儿童术后恶心呕吐更应该得到大众的关注。这篇文章综述了最近几十年对于预防儿童PONV的研究进展的总结。To date, postoperative nausea and vomiting (PONV) is still one of the serious complications during perioperative surgery, which increases the risk of surgical incision rupture and bleeding and may lead to aspiration pneumonia, electrolyte imbalance, dehydration and other adverse events, increases the length of hospital stay and costs, and affects the quality of life of patients after surgery to a certain extent. The prevention of postoperative nausea and vomiting is still one of the hot topics in clinical practice, especially the prevention of postoperative nausea and vomiting in children should receive more public attention. This article summarizes recent advances in research on the prevention of PONV in children.
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