Objective Excessive aluminum （Al） exposure impairs neurocognitive function in humans and animals. Epidemiologic studies have shown a potential linkage between chronic Al exposure and Alzheimer’s disease. The presen...
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Objective Excessive aluminum （Al） exposure impairs neurocognitive function in humans and animals. Epidemiologic studies have shown a potential linkage between chronic Al exposure and Alzheimer’s disease. The present study aims to evaluate the effects of tetrahydroxy stilbene glucoside （TSG）, the extract from herbal medicine Polygoni Multiflori, on cognitive impairment and the over-expression of hippocampal amyloid precursor protein （APP） induced by chronic exposure to Al in rats. Methods Rats were treated with 0.3% aluminum chloride （AlCl3） prepared in the drinking water for 90 d. AlCl3-treated animals were then randomly assigned to receive vehicle, TSG （4 g/kg）, or Vitamin E （VE; 40 mg/kg） treatment for 5 months. VE served as a positive control. The effect of TSG was evaluated by passive avoidance task, and APP expression was evaluated by Western blotting. Results Following exposure to AlCl3 for 90 d, animals displayed a striking decrease （〉80%） in step-through latency in the passive avoidance task and a significant increase in the expression of APP in the hippocampus. Both TSG and VE significantly ameliorated the performance impairment in the passive avoidance task, and suppressed the over-expression of APP. Moreover, the effects of TSG, but not of VE, were in a time-dependent manner. Conclusion TSG may possess therapeutic effects against Alzheimer’s disease.
1病历资料患者男,74岁,因'头晕3 d'来我院就诊。患者2015-04-21在家活动时无诱因出现头晕症状,伴有视物旋转,视物模糊、四肢乏力、行走不稳等症状,就诊于我院急诊,头颅CT排除'脑出血、急性脑梗死'后,以'脑血管病后遗症、高血压病'收入我科。既往有高血压病史45年,血压最高达220/100 mm Hg(1 mm Hg=0.133 k Pa),曾因血压控制不佳于1997年、
某些睡眠障碍疾病以夜间反复刻板的异常运动为特征，如抽动、扭动、磨牙等，有人将这类发生在睡眠期间的异常运动统称为夜间运动障碍（nocturnal movement disorders）。实际上，在国际睡眠障碍分类中并没有夜间运动障碍这一名称，临床...
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某些睡眠障碍疾病以夜间反复刻板的异常运动为特征，如抽动、扭动、磨牙等，有人将这类发生在睡眠期间的异常运动统称为夜间运动障碍（nocturnal movement disorders）。实际上，在国际睡眠障碍分类中并没有夜间运动障碍这一名称，临床上常见的周期性肢动症、不宁腿综合征属内源性睡眠障碍，节律性运动障碍、睡眠磨牙症等以属于异态睡眠（parasomnia）。
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