目的系统评价舍曲林对抑郁合并心力衰竭患者的治疗效果,为临床治疗抑郁合并心力衰竭提供参考依据。方法在知网、维普、CBM、PubMed、Embase、Cochrane Library、Web of Science数据库中检索舍曲林治疗抑郁合并心力衰竭的随机对照试验(R...
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目的系统评价舍曲林对抑郁合并心力衰竭患者的治疗效果,为临床治疗抑郁合并心力衰竭提供参考依据。方法在知网、维普、CBM、PubMed、Embase、Cochrane Library、Web of Science数据库中检索舍曲林治疗抑郁合并心力衰竭的随机对照试验(RCT)文献,检索时间均从建库至2022年12月。由2名研究人员依据纳入及排除标准进行文献筛选,提取汉密尔顿抑郁量表(HAMD)、左心室射血分数(LVEF)为结局指标。采用Cochrane偏倚风险评估工具对纳入文献进行质量评价,采用RevMan5.3软件进行Meta分析。结果共纳入4篇RCT文献,450例患者,其中试验组227例,对照组223例。Meta分析结果显示,试验组与对照组的HMAD评分比较,差异无统计学意义[均数差(MD)=-3.74,95%CI=-7.83~0.34,Z=1.80,P>0.05];试验组的LVEF显著高于对照组,差异具有统计学意义(MD=4.19,95%CI=3.01~5.36,Z=6.96,P<0.05)。结论舍曲林能够改善左心室收缩功能,可在某种程度上用于治疗抑郁合并心力衰竭,但对其他心脏指标和心功能的影响尚待进一步探究。
目的:分析成年人甘油三酯葡萄糖乘积(TyG)指数与2型糖尿病(T2DM)伴超重/肥胖状况之间的影响因素。方法:本研究选取60例T2DM伴超重/肥胖的患者组成患病组,同时选取30名健康个体构成健康对照组。收集两组的基本信息、检验参数指标,行统计学分析。结果:健康组与患病组在TyG指数、甘油三酯水平(TG)、空腹血糖值(FPG)、体重指数(BMI)、糖化血红蛋白(HbA1c)、红细胞计数(RBC)及空腹C肽浓度(FCP)等指标方面有显著差异。TyG指数、BMI的升高以及HbA1c的上升伴随RBC的下降,是T2DM伴超重/肥胖的独立风险因素。ROC曲线下面积(AUC)为0.841。结论:TyG指数在T2DM伴超重/肥胖人群的诊断与预测中发挥着重要作用。Objective: To analyze the influencing factors between adult triglyceride glucose product (TyG) index and type 2 diabetes mellitus (T2DM) with overweight and obesity. Methods: In this study, 60 patients with T2DM with overweight and obesity were selected to form the disease group, and 30 healthy individuals were selected to form the healthy control group to collect basic information of the two groups. The parameters were tested and the difference was compared by binary and multi-factor Logistic regression ROC curve. Results: TyG index, triglyceride level (TG), fasting blood glucose value (FPG), body mass index (BMI), glycosylated hemoglobin (HbA1c) in the healthy group and the diseased group. There were significant differences in red blood cell count (RBC) and fasting C-peptide concentration (FCP), and the increase of TyG BMI and HbA1c were accompanied by the decrease of RBC. The area under ROC curve (AUC) of T2DM with overweight and obesity was 0.841. Conclusion: TyG index plays an important role in the diagnosis and prediction of T2DM patients with overweight and obesity.
目的:探讨腰高比(WHtR)、内脏脂肪面积(VFA)对多囊卵巢综合征(PCOS)合并超重/肥胖患者生殖内分泌指标的相关性。旨在为PCOS合并超重/肥胖的辅助诊断和风险预测提供新依据。方法:本研究选取2023年9月至2024年5月期间,在包头医学院第一附属医院的内分泌科与妇产科治疗的85例PCOS患者作为研究样本,并选择同期在本院进行健康检查的30位女性作为对照组。收集研究对象临床基本资料,包括患者的年龄、身高、腰围、体重、VFA、SFA。收集临床生化指标包括性激素六项和AMH(抗缪勒氏管激素)的结果,通过生物电阻抗法测量内脏脂肪面积(VFA)和皮下脂肪面积(SFA),结果以平方厘米(cm2)为单位表示。各项指标的统计学分析则使用SPSS 29.0软件对三组研究对象的数据进行处理,Pearson法分析PCOS合并超重/肥胖患者WHtR、VFA与生殖内分泌指标的相关性。结果:超重/肥胖组患者的体重、体质指数(BMI)、腰围、腰高比、VFA及SFA均显著高于健康对照组和正常体重组(P 0.05)。健康对照组、正常体重组、超重/肥胖组患者在睾酮(T)、泌乳素(PRL)、LH/FSH (黄体生成素/卵泡刺激素)、AMH中具有显著差异(P 0.05)。三组患者在吸烟、饮酒、运动上无显著差异,健康对照组、正常体重组比超重/肥胖组在饮食上更倾向于低盐低脂,具有显著差异(P 0.05);VFA与LH水平呈负相关(r = −0.267, P 0.05);腰高比与VFA呈正相关(r = 0.368, P Objective: To explore the correlation between WHtR (WHtR) and visceral fat area (VFA) on reproductive endocrine indexes of patients with polycystic ovary syndrome (PCOS) complicated with overweight/obesity. It aims to provide a new basis for the auxiliary diagnosis and risk prediction of PCOS complicated with overweight/obesity. Methods: During September 2023 to May 2024, 85 PCOS patients who were treated in the Department of Endocrinology and Obstetrics and Gynecology of the First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology were selected as the research samples, and 30 women who underwent health examination in our hospital during the same period were selected as the control group. Collect the basic clinical data of the subjects, including age, height, waist circumference, weight, VFA and SFA. The results of clinical biochemical indexes including six sex hormones and AMH (anti-Miao Lei’s hormone) were collected. Visceral fat area (VFA) and subcutaneous fat area (SFA) were measured by bioelectrical impedance method, and the unit was cm2. SPSS 29.0 software was used to analyze the indexes of the three groups, and Pearson method was used to analyze the correlation between WHtR, VFA and reproductive endocrine indexes in PCOS patients with overweight/obesity. Results: The wei
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