Six linear nitrones,three DBN derivatives and their phosphoryl analogues,were first synthesized in this article,and the structures of their O-·2-spin trapping products,the nitroxides,were theoretically and experi...
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Six linear nitrones,three DBN derivatives and their phosphoryl analogues,were first synthesized in this article,and the structures of their O-·2-spin trapping products,the nitroxides,were theoretically and experimentally *** theoretical calculations on the optimized geometries of the spin adducts,using DFT method at B3LYP/6-311+G(d,p)//B3LYP/6-31G(d) level,demonstrated that both the intromolecular H-bonds and their internal rotations around C—N bond are the key factors for stabilizing the spin adducts.
L-Tyr-EMPO,a new EMPO analogue bearing an L-tyrosine methyl ether group,was first synthesized by *** radicals,including O-·2,·OH,·OR,and ·R,have been efficiently detected and characterized via *** ...
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L-Tyr-EMPO,a new EMPO analogue bearing an L-tyrosine methyl ether group,was first synthesized by *** radicals,including O-·2,·OH,·OR,and ·R,have been efficiently detected and characterized via *** half-life of the L-Tyr-EMPO superoxide adduct was estimated to be ca.6.5 *** importantly,the present study demonstrated a new synthetic strategy for covalent conjugation between cyclic-nitrone and amino group in peptides or proteins,by which the site-specifically spin trapping can be performed via antibody linked nitrone in the near ***,with the help of the covalent link,the targeting for the areas of interest in which the monitored radical species was sitespecially generated.
The synthesis of a novel α phosphorus containing spin trap, DEPDMPO(5 diethoxy Phosphoryl 2, 5 dimethyl 1 pyrroline \%N\% oxide) and the evaluation of its ability to spin trap the hydroxyl and the superoxide anion ra...
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The synthesis of a novel α phosphorus containing spin trap, DEPDMPO(5 diethoxy Phosphoryl 2, 5 dimethyl 1 pyrroline \%N\% oxide) and the evaluation of its ability to spin trap the hydroxyl and the superoxide anion radicals were described in the present article. The ability to trap an active superoxide anion radical generated in the photo system Ⅱ(PSII) and the stability of their spin adduct of DEPDMPO as well as three previously reported traps DMPO, DEPMPO and M 3PO were comparatively analyzed according to their chemical structures. In addition, the effects of 2 methyl and \%α\% phosphoryl substituted analogues of DMPO on the stabilities of the corresponding spin adduts were systematically
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