Background: The Tumor necrosis factor (TNF) is an established therapeutic target for rheumatoid arthritis and other autoimmune *** 5 TNF antagonists available on market now are all protein therapeutics.A major problem...
详细信息
Background: The Tumor necrosis factor (TNF) is an established therapeutic target for rheumatoid arthritis and other autoimmune *** 5 TNF antagonists available on market now are all protein therapeutics.A major problem limiting development of protein therapeutics is their sensitivity to proteases and delivery challenges.D-Peptides are highly resistant to natural proteases because of the stereospecificity.
Background: Allosteric drugs, taking an action-at-a-distance mechanism to achieve regulations on the protein functions, have several advantages over conventional orthosteric drugs, including diverse regulation types a...
详细信息
Background: Allosteric drugs, taking an action-at-a-distance mechanism to achieve regulations on the protein functions, have several advantages over conventional orthosteric drugs, including diverse regulation types and fewer side *** rational design of allosteric ligands, however, remains challenging, especially for the step of allosteric site *** allosteric ligand binding may work by inducing changes in the pattern of residue-residue interactions, we calculated the residue-residue interaction energies within the allosteric site based on the molecular mechanics generalized Born surface area (MM/GBSA) energy decomposition scheme.
暂无评论