Background: Xuesaitong soft capsule (XST) which consists of panax notoginseng saponin (PNS) has been used to treat ischemic cerebrovascular diseases in *** therapeutic mechanism of XST has not been elucidated yet from...
Background: Xuesaitong soft capsule (XST) which consists of panax notoginseng saponin (PNS) has been used to treat ischemic cerebrovascular diseases in *** therapeutic mechanism of XST has not been elucidated yet from prospective of genomics and ***: A transcriptome analysis was performed to review series concerning middle cerebral artery occlusion (MCAO) rat model and XST intervention after MCAO from Gene Expression Omnibus (GEO) *** expressed genes (DEGs) were compared between blank group and model group,model group and XST *** enrichment and pathway analysis were ***-Protein interaction network was *** overlapping genes from two PPI networks were screened out and profound analysis was ***: Two series including 22 samples were obtained.870 DEGs were identified between blank group and model group,and 1189 DEGs were identified between model group and XST *** terms and KEGG pathways of MCAO and XST intervention were significantly *** networks were constructed to demonstrate the gene-gene *** overlapping genes from two DEGs sets were ***2,Fhl3,Prep,Tyrobp,Tp53,Cdk2,SMAD4 and Stat1 were the pivotal genes and possible action sites of XST therapeutic ***: MCAO is a pathological process with multiple *** could achieve therapeutic effects on ischemic cerebrovascular diseases via specific genes.
暂无评论