Objective Nitric oxide （NO） was speculated to play an Minocycline, a tetracycline derivative, reduced inflammation important role in the pathophysiology of cerebral ischemia. and protected against cerebral ischemia....
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Objective Nitric oxide （NO） was speculated to play an Minocycline, a tetracycline derivative, reduced inflammation important role in the pathophysiology of cerebral ischemia. and protected against cerebral ischemia. To study the neuroprotection mechanism of minocycline for vascular dementia, the influences of minocycline on expressions of inducible nitric oxide synthase （iNOS） and endothelial nitric oxide synthase （eNOS） were observed in the brains of Wistar rats. Methods The vascular dementia rat model was established by permanent bilateral common carotid arteries occlusion （BCCAO）. Wistar rats were divideded into 3 groups randomly： sham-operation group （S group）, vascular dementia model group （M group）, and minocycline treatment group （MT group）. The behaviour was tested with Morris water maze and open-field task. Expressions of iNOS and eNOS were measured by immunohistochemistry and reverse transcriptase-polymerase chain reaction （RT-PCR）. The optical density value was measured by imaging analysis. Percentage of positive ceils with iNOS and eNOS expression was analyzed with optical microscope. Results Minocycline attenuated cognitive impairment. Inducible NOS was significantly down-regulated in MT group, compared with that in M group （P 〈 0.01）, while eNOS was significantly up-regulated, compared with that in M group （P 〈 0.01）. The expressions of iNOS and eNOS in M and MT groups were higher than those in S group （P 〈 0.01）. Conclusion Minocycline can down-regulate the expression of iNOS and up-regulate the expression of eNOS in vascular dementia, which restrains apoptosis and oxidative stress to protect neural function.
国家教育部在2001年提出加强大学本科教学的12项措施,其中要求各高校在3年内开设5%~10%的双语课程,并引进原版教材和提高师资水平。“双语”,英文是“B ilingua l”,直接的意思就是:“Tw o L anguages”(两种语言),是指在某个国家或某...
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国家教育部在2001年提出加强大学本科教学的12项措施,其中要求各高校在3年内开设5%~10%的双语课程,并引进原版教材和提高师资水平。“双语”,英文是“B ilingua l”,直接的意思就是:“Tw o L anguages”(两种语言),是指在某个国家或某个地区有两个(或两个以上)民族同时存在,并存在两种或两种以上文化历史背景条件下,可能或必须运用两种语言进行交流的情景[1]。这两种语言中,通常有一种是母语或本族语,而另一种语言往往是后天习得的第二种语言或者是外国语。双语教学,即用非母语进行部分或全部非语言学科的教学,一般是指用英语进行学科教学的一种体系。我国目前推崇的双语教学是指除汉语外,用英语作为课堂的主要用语进行学科教学的活动。它要求用准确、流利的英语进行知识的讲解,但不绝对排除汉语,以避免由于语言障碍造成学生对专业知识的理解困难而影响教学效果。近年,我们积极响应学校推广双语教学的号召,开展了神经病学双语教学,现结合我们进行双语教学的实践,谈谈认识。1对双语教学模式的理解[2]双语教学的基本模式包括3种理解:①“完全浸身目标语”模式(Imm ers ion M ode l),在使用这种模式的学校中...
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