Four new diorganotin complexes were synthesized and characterized by IR and 1H *** in vitro antitumor activities against a series of human tumor cell lines such as P 388 tumor cells were *** results showed that the co...
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Four new diorganotin complexes were synthesized and characterized by IR and 1H *** in vitro antitumor activities against a series of human tumor cell lines such as P 388 tumor cells were *** results showed that the complexes mainly exhibited strong antitumor activities against P 388 ,but presented no activities against other tumor cell *** structure activity relationships were discussed.
Ebselen. 2-phenyl-1, 2-benzisoselenazol-3 (2H)-one, activated by. glutathione(GSH) was shown to react with N-acetyl-p-benzoquinone imine (NAPQI). the toxic rnetabolite ofparacetamol, but not to react with paracetamol....
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Ebselen. 2-phenyl-1, 2-benzisoselenazol-3 (2H)-one, activated by. glutathione(GSH) was shown to react with N-acetyl-p-benzoquinone imine (NAPQI). the toxic rnetabolite ofparacetamol, but not to react with paracetamol. The GSH-activaled ebselen reacts uith NAPQI fasterand more complete than with ebselen alone. Compared xvith the UV-spectra of the solution containing20 μmol/L ebselen tactivated by 20 pmol/L GSH) and 20 pmol/L NAPQI with the solution contain-ing 20 μmol/L ebselen tactivated by 20 μmol/LGSH) and 20 μmol/L paracetamol, NAPQI was foundto be reduced to paracetamol by activated ebselen. The optimal PH range for this reaction was foundto be 7.4 to 8.2.
We have synthesized the novel compounds 1a-1i,which are a series of hybrid analogues to 6-benzyl-1-（benzyloxymethyl）- 5-iodouracil,a compound showing strong activity against *** also evaluated the activity of these ...
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We have synthesized the novel compounds 1a-1i,which are a series of hybrid analogues to 6-benzyl-1-（benzyloxymethyl）- 5-iodouracil,a compound showing strong activity against *** also evaluated the activity of these compounds as the inhibitors of HIV-1 reverse transcriptase（HIV-1 RT）,and they have demonstrated moderate activity.
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