Population pharmacokinetic meta-analysis method was used in order to obtain the pharmacokinetic characteristics of risperidone and its active metabolite. Eighteen studies were selected from published papers from 1995 ...
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Population pharmacokinetic meta-analysis method was used in order to obtain the pharmacokinetic characteristics of risperidone and its active metabolite. Eighteen studies were selected from published papers from 1995 to 2011. A model consisted of two compartments for parent drug and one compartment for its active metabolite combined with a flexible absorption process was developed based on the meta-dataset. The population-predicted apparent clearance for risperidone and 9-hydroxyrisperidone, the active metabolite was 7.66 L/h and 7.38 L/h, and the apparent volume of distribution in the central compartment was 70.6 L and 117 L, respectively. The final model was evaluated by visual predictive check（VPC） based on 1000 times model simulation. This model was adequately used to predict clinical therapeutic drug monitoring（TDM） data from 42 Chinese inpatients. Bias（mean prediction errors, MPE） and precision（root mean squared prediction errors, RMSE） were calculated to statistically analysis the population prediction error. It was demonstrated that the model developed from the meta-dataset was reliable and can be used to facilitate the individualized treatment for a target population.
近日,北京大学药学院天然药物及仿生药物国家重点实验室杜权团队和首都医科大学附属北京友谊医院杨瑛团队合作,在口腔医学领域权威期刊International Journal of Oral Science(即时IF:19.768)上发表论文“The enhanced genomic 6 mA met...
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近日,北京大学药学院天然药物及仿生药物国家重点实验室杜权团队和首都医科大学附属北京友谊医院杨瑛团队合作,在口腔医学领域权威期刊International Journal of Oral Science(即时IF:19.768)上发表论文“The enhanced genomic 6 mA metabolism contributes to the proliferation and migration of TSCC cells”,揭示了基因组DNA的6mA修饰与舌癌病理过程的密切相关,证实了舌癌细胞基因组6mA修饰参与了肿瘤细胞的增殖和迁移,为舌癌的致病机制研究开辟了新的思路。
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