Background The use oftitanium during maxillofacial fixation is limited due to its palpability, mutagenic effects and interference with imaging, which lead to the requirement for subsequent *** use of a biologically ab...
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Background The use oftitanium during maxillofacial fixation is limited due to its palpability, mutagenic effects and interference with imaging, which lead to the requirement for subsequent *** use of a biologically absorbable fixation material will potentially eliminate these *** this meta-analysis, we analyzed the complications of absorbable fixation in maxillofaciul ***: We performed a systematic search of PubMed, Embase, Cochrane Central Register of Systematic Reviews and Cochrane Central Register of Controlled Trials for trials published, through December *** extracted from literature were analyzed with Review manager ***: Relevant data was extracted from 20 studies (1673 participants) and revealed that patients in the absorbable group had signi?cantly more complications than those in the titanium group (RR =1.20;95% CI: 1.02-1.42;P =0.03) in all enrolled maxillofacial *** bimaxillary operation subgroup, the absorbable fixation group did not have a significant increase in complications when compared with the titanium group (RR =1.89;95% CI: 0.85-4.22;P =0.12).There was no signi?cant difference observed between the absorbable and titanium groups receiving a bilateral sagittal split ramus osteotomy (BSSRO) (RR =1.45;95% CI: 0.84-2.48;P =0.18) and Le Fort I osteotomy (RR =0.65;95%CI: 0.34-1.23;P =0.18).The combined results of the five trials revealed that the absorbable group had a significantly lower rate of complications compared to the titanium group (RR =0.71;95% CI: 0.52-0.97;P =0.03) in fracture ***: This meta-analysis shows that absorbable fixation systems used for fixation in maxillofacial surgery do not have adequate safety *** indicated the safety of absorbable fixation systems was superior during fracture *** absorbable fixation systems tend to have a similar favorable safety profile as titanium fixation during Le Fort I, bimaxillary operation and BSSRO.
性发育疾病（Disorders of sex development，DSD）是性别决定和性分化异常的一组异质性遗传病，表现为遗传性别、性腺性别和表型性别的异常及不均一性，DSD的发病率约为1：5500。在2006年欧洲儿科内分泌及Lawson Wilkins儿科内分泌协...
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性发育疾病（Disorders of sex development，DSD）是性别决定和性分化异常的一组异质性遗传病，表现为遗传性别、性腺性别和表型性别的异常及不均一性，DSD的发病率约为1：5500。在2006年欧洲儿科内分泌及Lawson Wilkins儿科内分泌协会联合召开会议上，提出以DSD代替以雌雄间体、假两性畸形、真两性畸形和性反转等描述性发育疾病。我们主要对现阶段性发育疾病的诊断和治疗进展进行归纳和总结。
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