OBJECTIVE: Wolff-Parkinson-White syndrome (WPW) is considered to be an autosomal dominant hereditary disease, but the gene is not identified. The objective of this study was to localize the genetic loci of Wolff-Parki...
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OBJECTIVE: Wolff-Parkinson-White syndrome (WPW) is considered to be an autosomal dominant hereditary disease, but the gene is not identified. The objective of this study was to localize the genetic loci of Wolff-Parkinson-White syndrome. METHODS: Linkage analysis between the disease of Wolff-Parkinson-White syndrome and 3 STR (short tandem repeats) markers on 7q3 (D7S505, D7S688, and D7S483) was tested in 3 kindreds of the Wolff-Parkinson-White syndrome (101 numbers in total) by genotyping. RESULTS: Wolff-Parkinson-White syndrome was linked to the loci above. The maximum two-point Lod score detected at D7S505 was 6.4 at a recombination fraction (theta) of 0.1; the Lod score of D7S688, D7S483 was 5.3 vs 2.5. CONCLUSION: The gene of Wolff-Parkinson-White syndrome is located at 7q3.
患者女性,62岁,因发作性意识不清、四肢抽动、尿失禁16 h,以"癫痫持续状态"于1999年11月12日收入院.病前3 d有受凉史.体检:体温37.6℃,脉搏102次/min,呼吸28次/min,血压140/92 mm Hg(1 mm Hg = 0.133 kPa).浅昏迷,眼底检查正...
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患者女性,62岁,因发作性意识不清、四肢抽动、尿失禁16 h,以"癫痫持续状态"于1999年11月12日收入院.病前3 d有受凉史.体检:体温37.6℃,脉搏102次/min,呼吸28次/min,血压140/92 mm Hg(1 mm Hg = 0.133 kPa).浅昏迷,眼底检查正常,双瞳孔等大,对光反射存在,刺激四肢能屈伸.双Chaddock征(+).颈部抵抗,Kernig征(-).血白细胞7.6×109/L,中性多核细胞0.72,淋巴细胞0.28.
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