氟哌噻吨美利曲辛导致的迟发性运动障碍(tardive dyskinesia,TD)少见文献报告。本文报告1例高龄女性混合性焦虑抑郁障碍患者,服用氟哌噻吨美利曲辛1年后,出现不自主口-舌-颊动作,异常不自主运动量表(abnormal involuntary movement scal...
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氟哌噻吨美利曲辛导致的迟发性运动障碍(tardive dyskinesia,TD)少见文献报告。本文报告1例高龄女性混合性焦虑抑郁障碍患者,服用氟哌噻吨美利曲辛1年后,出现不自主口-舌-颊动作,异常不自主运动量表(abnormal involuntary movement scale,AIMS)评分为12分,诊断为TD,停用氟哌噻吨美利曲辛,未作其它处理。停药后TD症状在短暂加重后逐渐减轻,1年后完全消除,再评AIMS为0分。其转归较为特殊,有别于以往关于TD“不可逆”的普遍认识,值得同行关注和讨论。
目的:探讨注意缺陷多动障碍(ADHD)儿童在配对面孔比较任务中对不同模糊程度面孔进行知觉闭合加工的特点。方法:纳入符合美国精神障碍诊断与统计手册第4版(DSM-IV)中ADHD诊断标准的儿童33例,以及正常对照儿童26例。记录两组被试在观看遮挡面孔和完整面孔时的脑电信号,运用事件相关电位(event-related potentials, ERPs)技术比较两组儿童P1、N170和NCL指标波幅和潜伏期上的差异。结果:两组儿童P1成分无显著差异(p > 0.05),ADHD儿童N170潜伏期提前[(197.52 ± 1.52 ) ms vs. (204.58 ± 1.77) ms, p p p > 0.05)。结论:ADHD儿童知觉闭合加工存在明显缺陷,表现出左半球的代偿效应。Objective: To explore the characteristics of perceptual closure processing of faces with different degrees of blurriness in paired face comparison tasks in children with Attention Deficit/Hyperactivity Disorder (ADHD). Methods: 33 children who met the diagnostic criteria for ADHD in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV), and 26 normal control children were included. Record the EEG signals of two groups of subjects when viewing occluded and intact faces, and compare the differences in amplitude and latency of P1, N170, and NCL indicators between the two groups of children using event-related potentials (ERPs) technology. Results: There was no significant difference in the P1 component between the two groups of children (p > 0.05), and the latency of N170 was advanced in ADHD children [(197.52 ± 1.52) ms vs. (204.58 ± 1.77) ms, p p p > 0.05). Conclusions: Children with ADHD exhibit significant deficits in perceptual closure processing, displaying compensatory effects in the left hemisphere.
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