Myocardium hypertrophy is a compensated response to cardiac disease in which intracellular Ca2+ concentration is elevated,the essential signal that results in *** cardiac sodium-calcium exchanger(NCX) is a bidirection...
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Myocardium hypertrophy is a compensated response to cardiac disease in which intracellular Ca2+ concentration is elevated,the essential signal that results in *** cardiac sodium-calcium exchanger(NCX) is a bidirectional ion transporter in *** decrease in NCX activity as well as its inverse mode is one of the main mechanisms that contribute to cytosolic Ca2+ loading in *** extracellular signal molecules,the change of Na+ /Ca2+ concentrations and intracellular modulating proteins during cardiac hypertrophy can affect the activity or NCX function,and increase intracellular Ca2+.We summarized the regulatory mechanism of NCX in myocardium hypertrophy.
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