Background/Aims:Postoperative atrial fibrillation(AF)remains a common cause of *** evidence indicates that inflammation and atrial fibrosis contribute to its ***-17A,a potent proinflammatory cytokine,has been implicat...
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Background/Aims:Postoperative atrial fibrillation(AF)remains a common cause of *** evidence indicates that inflammation and atrial fibrosis contribute to its ***-17A,a potent proinflammatory cytokine,has been implicated in many cardiovascular ***,its role in postoperative AF remains ***:Sterile pericarditis(SP)was developed in rats by epicardial application of sterile *** was induced by transesophageal burst *** zymography and reverse gelatin zymography were used to quantify the matrix metalloproteinases(MMPs),and tissue inhibitors of MMPs(TIMPs).Results:SP rats showed shorter refractoriness,higher number and duration of AF,more likely to induce AF,increased m RNA levels of AF-related proinflammatory 1),as well as obviously atrial inflammation and β and TGF-βcytokines(IL-6,IL-1 *** IL-17A level was elevated and correlated with the probability of ***-IL-17A monoclonal antibody treatment reduced atrial IL-17A,prolonged refraction and markedly suppressed AF ***,inflammation and fibrosis was alleviated,which was further demonstrated by reduced AF-related proinflammatory cytokines expression,downregulated m RNA for-SMA),and reversed the activity of MMP-2/9 and β fibrosis(col-1,col-3,and ***:IL-17A may play a pathogenic role in postoperative AF by inducing inflammation and fibrosis in SP rats.
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