The flexibility of RNA in aqueous solution and crystal form has been studied through molecular dynamics simulation and database *** results demonstrated that"the flexibility is a dangerous word for describing mac...
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The flexibility of RNA in aqueous solution and crystal form has been studied through molecular dynamics simulation and database *** results demonstrated that"the flexibility is a dangerous word for describing macromolecules,unless it is clearly defined"[1].The circumstance for RNA is more complicate,since different from the helix structure of B-DNA and A-RNA duplexes,the secondary structure of single-stranded RNA has more structural components,including base-pairs,bulges,interior loops,end loops, multi branch loops etc.,and their complex combinatoriality[2].
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