Chronic allograft rejection,which is manifested as chronic allograft vasculopathy(CAV),continues to refrain the long-term success of small bowel transplantation(SBTx).The pathway mediated by the receptor for advanced ...
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Chronic allograft rejection,which is manifested as chronic allograft vasculopathy(CAV),continues to refrain the long-term success of small bowel transplantation(SBTx).The pathway mediated by the receptor for advanced glycation end products(RAGE) and its ligand,high mobility group box-1(HMGBl),may contribute to the pathogenesis of CAV,given that they were involved in the process of allograft rejection,n-3 polyunsaturated fatty acids(PUFAs),which has been discovered to attenuate CAV,may have potential impacts on this pathway. The present study investigated whether n-3 PUFAs attenuated CAV via the regulation of HMGB1-RAGE pathway in a chronic rejection model of rat *** revealed that the expression of HMGBl and RAGE was increased in CAV-bearing vessels as well as endothelial cells isolated from these *** administration of fish oil with high levels of n-3 PUFAs following SBTx significantly reduced the HMGBl and RAGE expression,which coincided with the amelioration of *** contrast,feeding of corn oil that contained low levels of n-3 PUFAs had no favorable effects on CAV development,and failed to decrease the HMGBl and RAGE *** results indicate that protective effects of n-3 PUFAs on allograft vessels exist via downregulation of HMGB1- RAGE pathway.
作者：
Fangcong Dong董方聪Bin Wang王斌Lulu Zhang张璐璐Yulan Wang王玉兰Jieshou Li黎介寿中国科学院研究生院
北京100049 Research Institute of General SurgeryNanjing General Hospital of Nanjing Military CommandPLA Nanjing 210002 P.R.China 南京军区南京总医院普通外科学研究所南京210002 State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsWuhan Center for Magnetic Resonance Wuhan Institute of Physics and MathematicsChinese Academy of Sciences Wuhan 430071 P.R.China 中国科学院武汉物理与数学研究所波谱与原子分子国家重点实验室武汉磁共振中心武汉430071 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics
Wuhan Center for Magnetic Resonance Wuhan Institute of Physics and MathematicsChinese Academy of Sciences Wuhan 430071 P.R.China Graduate School of Chinese Academy of Sciences
Beijing 100049 P.R.China 中国科学院武汉物理与数学研究所波谱与原子分子国家重点实验室武汉磁共振中心武汉430071
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