Chronic allograft rejection,which is manifested as chronic allograft vasculopathy(CAV),continues to refrain the long-term success of small bowel transplantation(SBTx).The pathway mediated by the receptor for advanced ...
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Chronic allograft rejection,which is manifested as chronic allograft vasculopathy(CAV),continues to refrain the long-term success of small bowel transplantation(SBTx).The pathway mediated by the receptor for advanced glycation end products(RAGE) and its ligand,high mobility group box-1(HMGBl),may contribute to the pathogenesis of CAV,given that they were involved in the process of allograft rejection,n-3 polyunsaturated fatty acids(PUFAs),which has been discovered to attenuate CAV,may have potential impacts on this pathway. The present study investigated whether n-3 PUFAs attenuated CAV via the regulation of HMGB1-RAGE pathway in a chronic rejection model of rat *** revealed that the expression of HMGBl and RAGE was increased in CAV-bearing vessels as well as endothelial cells isolated from these *** administration of fish oil with high levels of n-3 PUFAs following SBTx significantly reduced the HMGBl and RAGE expression,which coincided with the amelioration of *** contrast,feeding of corn oil that contained low levels of n-3 PUFAs had no favorable effects on CAV development,and failed to decrease the HMGBl and RAGE *** results indicate that protective effects of n-3 PUFAs on allograft vessels exist via downregulation of HMGB1- RAGE pathway.
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