Background and Objectives: Toll-like receptor 4 (TLR4) links human innate and adaptive immunity via bacterial endotoxin recognition, and has a considerable role in the pathogenesis of *** some genetic association stud...
Background and Objectives: Toll-like receptor 4 (TLR4) links human innate and adaptive immunity via bacterial endotoxin recognition, and has a considerable role in the pathogenesis of *** some genetic association studies on TLR4 and asthma have been performed, the effects of the genetic variants of TLR4 on asthma are still largely *** study aimed to evaluate the effects of polymorphisms in TLR4 on asthma risk and asthma-related phenotypes in a Chinese Han ***: We consecutively recruited 318 unrelated adult asthmatic patients and 352 healthy *** tagging single nucleotide polymorphisms (SNPs) in TLR4 gene were detected using GenomeLab SNPstream or TaqMans *** conducted case-control and case-only association studies between the selected tagging SNPs in TLR4 and asthma or asthma-related ***: We found no evidence to support a significant association between TLR4 SNPs and asthma ***, our results revealed that TT homozygote of rs1927914 was associated with lower FEV1% and FEV1/FVC in asthmatic *** evidently positive association was found between the TT genotype of rs1927914, or the GG genotype ofrs10983755 and rs1927907, and asthma severity (P=0.008, 0.002, 0.004, respectively), which indicated that C allele of rs 1927914, and A allele of rs 10983755 and rs 1927907 had a protective effect on asthma *** between genetic variants in TLR4 and other asthma-related phenotypes, such as eosinophil counts, serum high-sensitivity C reactive protein and total serum immunoglobulin E levels, were not ***: TLR4 polymorphisms do not contribute to asthma susceptibility, but may influence the severity of asthma.
目的中国西部地区男男性行为人群(Men who have sex with men,MSM)艾滋病病毒(Human immunodeficiency virus,HIV)感染率较高,对该地区MSM的艾滋病(Acquired immunodeficiency syndrome,AIDS)相关知识及行为进行调查,为制定该人群艾滋...
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目的中国西部地区男男性行为人群(Men who have sex with men,MSM)艾滋病病毒(Human immunodeficiency virus,HIV)感染率较高,对该地区MSM的艾滋病(Acquired immunodeficiency syndrome,AIDS)相关知识及行为进行调查,为制定该人群艾滋病防治策略及行为干预措施提供较为切实的依据和参考。方法研究设计为横断面调查,于2009年7月至2010年4月对我国西部的重庆、四川、广西三省市1 407名MSM进行问卷调查。结果 MSM的年龄中位数是26岁,同性恋者占69.26%,双性恋者占21.40%。艾滋病相关知识知晓率为88.37%。最近6个月,61.22%的MSM有2个及以上同性性伴,7.42%的有同性商业性行为,12.48%的有异性性行为。近6个月内男男肛交性行为时每次都坚持使用安全套的占46.40%。最近6个月与不同对象发生性行为时的安全套使用有差别(P<0.05)。不同地区、是否多性伴和是否有同性商业行为与安全套的使用有关联。结论中国西部地区MSM人群中普遍存在感染艾滋病的高危行为,且与其较高的艾滋病知识水平分离现象严重,这对该人群的行为干预提出了挑战,因此,探索控制MSM人群艾滋病传播的新干预模式具有重要意义。
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