Objective To investigate the role of tyrosine kinase receptor C（TrkC）,the receptor of neurotrophin-3（NT-3）,in neuroplasticity following spinal cord injury（SCI）.Methods Rats with cord transection were allowed to ...
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Objective To investigate the role of tyrosine kinase receptor C（TrkC）,the receptor of neurotrophin-3（NT-3）,in neuroplasticity following spinal cord injury（SCI）.Methods Rats with cord transection were allowed to survive for 1,3,7 and 14 d post operation（dpo）.TrkC expressions at lower thoracic levels of the spinal cord and in precentral gyrus of cerebral cortex were *** TrkC protein levels at both the site of injury（T10-T11） and the neighboring segments（T9 and T12） in the spinal cord decreased significantly at 1-7 dpo,followed by a rapid increase at 14 *** temporal changes in TrkC mRNA expression level showed a similar pattern with that of TrkC *** addition,the levels of TrkC protein and mRNA at the site of injury（T10-T11） were significantly higher than those at the neighboring spinal segments（T9 and T12）.Besides,the levels of TrkC protein and mRNA were higher at the rostral segment than at the caudal ***,in the motor cortex,TrkC protein was not detected and TrkC mRNA was expressed at a very low *** These results suggest that TrkC may be involved in neuroplasticity after SCI.
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