Depression is a chronic,recurring and potentially life-threatening illness that affects up to 20%of the population across the *** its prevalence and considerable impact on human,little is known about its *** of the ma...
详细信息
Depression is a chronic,recurring and potentially life-threatening illness that affects up to 20%of the population across the *** its prevalence and considerable impact on human,little is known about its *** of the major reasons is the restricted availability of validated animal models due to the absence of consensus on the pathology and etiology of ***,some core symptoms such as depressed mood,feeling of worthlessness,and recurring thoughts of death or suicide,are impossible to be modeled on laboratory ***,the criteria for identifying animal models of depression rely on either of the 2 principles：actions of known antidepressants and responses to *** review mainly focuses on the most widely used animal models of depression,including learned helplessness,chronic mild stress,and social defeat ***,the behavioral tests for screening antidepressants,such as forced swimming test and tail suspension test,are also *** advantages and major drawbacks of each model are *** prospective,new techniques that will be beneficial for developing novel animal models or detecting depression are discussed.
暂无评论